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人 CLEC1B/CLEC2 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
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10976-H07H-50
10976-H07H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
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50306-M01H-50
50306-M01H-100
50 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    10976-RP01-400
    10976-RP01-200
    10976-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10976-T16-50
      10976-T16-200
      10976-T16-100
      50 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        10976-R004-50
        10976-R004-100
        50 µg 
        100 µg 
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        CLEC1B/CLEC2 cdna-clone 研究背景

        CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC2 contains 1 C-type lectin domain and is expressed preferentially in the liver. It acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.

         CLEC1B/CLEC2 cdna-clone 参考资料
      • Suzuki-Inoue K, et al. (2007) Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. J Biol Chem. 282(36):25993-6001.
      • Watson AA, et al. (2007) The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2. J Biol Chem. 282(5):3165-72.
      • Chaipan C, et al. (2006) DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J Virol. 80(18):8951-60.
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