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人 CD3e/CD3 epsilon 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

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表达宿主: Human Cells  
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10977-H08H-50
10977-H08H-20
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20 µg 
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表达宿主: Human Cells  
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10977-H03H-50
10977-H03H-20
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20 µg 
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表达宿主: Human Cells  
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80452-R02H-20
80452-R02H-100
20 µg 
100 µg 
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表达宿主: Human Cells  
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70106-D02H-20
70106-D02H-100
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100 µg 
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表达宿主: Human Cells  
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90047-C03H-20
90047-C03H-100
20 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
90047-C02H-50
90047-C02H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
90047-C08H-50
90047-C08H-20
50 µg 
20 µg 
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反应性: Human  
应用 : FCM  
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10977-M001-C-25
10977-M001-C-100
25 Test 
100 Tests 
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反应性: Human  
应用 : FCM  
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10977-M001-F-25
10977-M001-F-100
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100 Tests 
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反应性: Human  
应用 : FCM  
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10977-M001-P-25
10977-M001-P-100
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100 Tests 
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反应性: Human  
应用 : FCM  
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10977-M001-A-25
10977-M001-A-100
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100 Tests 
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反应性: Human  
应用 : ELISA  
    10977-RP01-400
    10977-RP01-200
    10977-RP01-100
    400 µg 
    200 µg 
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    反应性: Human  
    应用 : WB  IP  
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    10977-R801-50
    10977-R801-100
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    100 µg 
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    反应性: Human  
    应用 : FCM  
    • Slide 1
    10977-M001-50
    10977-M001-200
    10977-M001-100
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    200 µg 
    100 µg 
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    反应性: Human  
    应用 : FCM  Func/A  
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    10977-H001-500
    10977-H001-100
    10977-H001-1
    500 µg 
    100 µg 
    1 mg 
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    反应性: Human  
    应用 : ELISA  
      10977-T16-50
      10977-T16-200
      10977-T16-100
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      200 µg 
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      反应性: Human  
      应用 : ELISA  
        10977-R822-50
        10977-R822-100
        50 µg 
        100 µg 
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        反应性: Human  
        应用 : ELISA  
          10977-MM03-50
          10977-MM03-100
          50 µg 
          100 µg 
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          反应性: Human  
          应用 : ELISA  IP  
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          10977-T20-50
          10977-T20-200
          10977-T20-100
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          200 µg 
          100 µg 
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          反应性: Human  
          应用 : WB  
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          100216-T32-50
          100216-T32-200
          100216-T32-100
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          200 µg 
          100 µg 
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          反应性: Human  
          应用 : 
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          GMP-10977-H001-100
          GMP-10977-H001-1
          100 µg 
          1 mg 
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          反应性: Human  
          应用 : 
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          CT026-R301-F-25
          CT026-R301-F-100
          25 Test 
          100 Tests 
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          反应性: Human  
          应用 : 
          • Slide 1
          CT026-R301-A-25
          CT026-R301-A-100
          25 Test 
          100 Tests 
          Add to Cart

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          CD3e/CD3 epsilon cdna-clone 研究背景

          T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.

          Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

           CD3e/CD3 epsilon cdna-clone 参考资料
        • Fischer A, et al. (2005) CD3 deficiencies. Curr Opin Allergy Clin Immunol. 5(6): 491-5.
        • Wang Y, et al. (2009) A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. PLoS Biol. 7(12): e1000253.
        • Martnez-Martn N, et al. (2009) Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon. Sci Signal. 2(83): ra43.
        • Deford-Watts LM, et al. (2009) The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions. J Immunol. 183(2): 1055-64.
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