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大鼠 CSRP1 基因ORF全长cDNA克隆(表达载体)

产品数据评论实验方法
表达宿主: E. coli  
  • Slide 1
11201-H08E-50
11201-H08E-20
50 µg 
20 µg 
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表达宿主: E. coli  
  • Slide 1
50532-M08E-20
50532-M08E-100
20 µg 
100 µg 
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反应性: Human  
应用 : ELISA  WB  IP  
  • Slide 1
  • Slide 1
11201-RP02-50
11201-RP02-200
11201-RP02-100
50 µg 
200 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    11201-RP01-400
    11201-RP01-200
    11201-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反应性: Mouse  
    应用 : ELISA  WB  IP  
    • Slide 1
    • Slide 1
    50532-T52-50
    50532-T52-200
    50532-T52-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart

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    CSRP1 cdna-clone 研究背景

    Cysteine and glycine-rich protein 1, also known as Cysteine-rich protein 1, CSRP1 and CSRP, is a member of the CSRP family which may be involved in regulatory processes important for development and cellular differentiation. CSRP1 contains two LIM zinc-binding domains. The LIM / double zinc-finger motif found in CSRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Zebrafish CSRP1 is expressed in the mesendoderm and its derivatives. CSRP1 interacts with Dishevelled 2 (Dvl2) and Diversin (Div), which control cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways. When CSRP1 message is knocked down, abnormal convergent extension cell movement is induced, resulting in severe deformities in midline structures. In addition, cardiac bifida is induced as a consequence of defects in cardiac mesoderm cell migration. CSRP1 acts as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs.

    大鼠 CSRP1 cdna-clone 参考资料
  • Wimmer,U. et al., 2005, Nucleic acids Res. 33 (18):5715-27.
  • Miyasaka, KY.et al., 2007, Proc Natl Acad Sci USA. 104 (27): 11274-9.
  • Zhou,C.Z. et al., 2008,Chin Med J. 121 (24): 2479-86.
  • Lilly,B. et al., 2010, Arterioscler Thromb Vasc Biol. 30 (4):694-701. 
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