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大鼠 Decorin/DCN 基因ORF全长cDNA克隆(表达载体)

产品数据评论实验方法
表达宿主: Human Cells  
  • Slide 1
10189-H01H-200
10189-H01H-100
200 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
10189-H08H-200
10189-H08H-100
200 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  
    10189-RP01-400
    10189-RP01-200
    10189-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : ELISA  
      10189-RP02-50
      10189-RP02-200
      10189-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : ELISA  
        10189-R004-50
        10189-R004-100
        50 µg 
        100 µg 
        Add to Cart
        反应性: Human  
        应用 : 
          10189-T16-50
          10189-T16-200
          10189-T16-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart

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          Decorin/DCN cdna-clone 研究背景

          Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.

          大鼠 Decorin/DCN cdna-clone 参考资料
        • Mogyorsi A, et al. (1999) What is the role of decorin in diabetic kidney disease? Nephrol Dial Transplant. 14(5): 1078-81.
        • Reed CC, et al. (2002) The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J. 19(4-5): 249-55.
        • Goldoni S, et al. (2008) Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int J Cancer. 123(11): 2473-9.
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