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人 CCL8/MCP-2 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
表达宿主: E. coli  
  • Slide 1
10989-H21E-20
10989-H21E-10
20 µg 
10 µg 
Add to Cart
表达宿主: Yeast  
  • Slide 1
10989-H08Y-50
10989-H08Y-10
50 µg 
10 µg 
Add to Cart
表达宿主: E. coli  
  • Slide 1
50181-M24E-50
50181-M24E-20
50 µg 
20 µg 
Add to Cart
反应性: Mouse  
应用 : ELISA  IHC-P  
  • Slide 1
  • Slide 1
50181-T24-50
50181-T24-200
50181-T24-100
50 µg 
200 µg 
100 µg 
Add to Cart
反应性: Mouse  
应用 : ELISA  
    50181-RP01-400
    50181-RP01-200
    50181-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart

    CCL8/MCP-2 cDNARelated Products

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    CCL8/MCP-2 cdna-clone 研究背景

    Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP-2), is a small cytokine belonging to the C-C chemokine family. CCL8 functions to activate different immune cells, including mast cells, eosinophils and basophils which are involved in allergic responses, monocytes, and T cells and NK cells which are involved in the inflammatory response. CCL8's ability achieves by binding to different cell surface receptors termed chemokine receptors including CCR1, CCR2B and CCR5. It has been reported that CCL8 is a potent inhibitor of HIV-1 by virtue of its binding to CCR5 which is one of the major co-receptors for HIV-1.

     CCL8/MCP-2 cdna-clone 参考资料
  • Laing KJ, et al. (2004) Chemokines. Developmental and comparative immunology. 28 (5): 443-60.
  • Cocchi F, et al. (1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8+ T cells. Science. 270 (5243): 1811–5.
  • Hori T, et al. (2008) CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease. Blood. 111 (8): 4403-12.
  • Biber K, et al. (2003) Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8. Journal of Leukocyte Biology. 74 (2): 243-51.
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    CCL8/MCP-2 related areas, pathways, and other information

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