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人 AGT 基因全长ORF克隆 (表达载体), N端FLAG标签

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表达宿主: Human Cells  
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10994-H08H-10
10994-H08H-20
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表达宿主: Human Cells  
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50337-M08H-50
50337-M08H-100
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表达宿主: Human Cells  
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81380-R08H-100
81380-R08H-20
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反应性: Human  
应用 : FCM  
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10994-MM08-P-50
10994-MM08-P-100
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反应性: Human  
应用 : ELISA  
    10994-RP01-100
    10994-RP01-200
    10994-RP01-400
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    反应性: Human  
    应用 : ELISA  IHC-P  
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    10994-RP02-50
    10994-RP02-100
    10994-RP02-200
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    反应性: Human  
    应用 : ELISA  WB  IF  IP  ICC/IF  
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    10994-R001-50
    10994-R001-100
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    100 µg 
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    反应性: Human  
    应用 : FCM  
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    10994-MM08-50
    10994-MM08-100
    10994-MM08-200
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    100 µg 
    200 µg 
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    反应性: Human  
    应用 : FCM  
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    10994-R001-F-50
    10994-R001-F-100
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    反应性: Human  
    应用 : IHC-P  
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    10994-R034-50
    10994-R034-100
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    100 µg 
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    反应性: Human  
    应用 : FCM  
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    10994-R001-P-100
    10994-R001-P-50
    100 Tests 
    50 Tests 
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    反应性: Mouse  
    应用 : ELISA  
      50337-RP01-400
      50337-RP01-100
      50337-RP01-200
       
      100 µg 
      200 µg 
      Add to Cart
      反应性: Mouse  
      应用 : ELISA  WB  
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      50337-RP02-200
      50337-RP02-50
      50337-RP02-100
      200 µg 
      50 µg 
      100 µg 
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      Angiotensinogen/SerpinA8 cdna-clone 研究背景

      Angiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. Angiotensinogen can be schematically considered to consist of a combination of an angiotensin I (Ang I) function, located at the N-terminal end, and the presence of a serpin (serine protease inhibitor) structure at the opposite end. Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system. Defects in AGT are associated with susceptibility to essential hypertension and renal tubular dysgenesis (RTD). Several serpins (antithrombin, maspin, pigment epithelial-derived factor, and kallistatin) have been recently shown to exert an antiangiogenic activity, suggesting a common mechanism of endothelial cell proliferation and migration. Angiotensinogen/AGT and its renin-cleaved product, des(Ang I)AGT, are also angiogenesis inhibitors, both in vitro and in vivo at concentrations within the range of those observed in plasma. The Angiotensinogen products, that is angiotensin II and possibly angiotensin II-related products, have been found to act locally in modulating adipose tissue growth in an autocrine/paracrine manner. The transient or chronic overexpression of angiotensinogen in adipose tissue favors lipogenesis in adipocytes and leads to a 'vicious' circle whereby adipose tissue development is further increased.

      Human Angiotensinogen/SerpinA8 cdna-clone 参考资料
    • Ailhaud G, et al. (2002) Angiotensinogen, adipocyte differentiation and fat mass enlargement. Curr Opin Clin Nutr Metab Care. 5(4): 385-9.
    • Corvol P, et al. (2003) Inhibition of angiogenesis: a new function for angiotensinogen and des(angiotensin I)angiotensinogen. Curr Hypertens Rep. 5(2): 149-54.
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