Anti-gp130 / IL6ST Antibody

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Anti-gp130 / IL6ST Antibody (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-gp130 / IL6ST Antibody
经验证的应用
IHC-P
交叉反应
Reacts with: Mouse
特异性
Mouse gp130 / IL6ST
免疫原
Recombinant Mouse gp130 / CD130 / IL6ST protein (Catalog#50135-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse gp130 / CD130 / IL6ST (rM gp130 / CD130 / IL6ST; Catalog#50135-M08H; NP_034690.3; Met1-Glu617).
来源
Monoclonal Rabbit IgG Clone #223
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-gp130 / IL6ST Antibody (Rabbit Monoclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
IHC-P 1:5000-1:20000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-gp130 / IL6ST Antibody (Rabbit Monoclonal 抗体) 图片

Immunochemical staining of mouse IL6ST in mouse heart with rabbit monoclonal antibody (1:10000, formalin-fixed paraffin embedded sections).
Immunochemical staining of mouse IL6ST in mouse brain with rabbit monoclonal antibody (1:10000, formalin-fixed paraffin embedded sections).

Anti-gp130 / IL6ST Antibody: 别称

Anti-5133400A03Rik Antibody; Anti-AA389424 Antibody; Anti-BB405851 Antibody; Anti-CD130 Antibody; Anti-D13Ertd699e Antibody; Anti-gp130 Antibody

gp130 / IL6ST 背景信息

Glycoprotein 13 (also known as gp13, IL6ST, IL6-beta or CD13) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD13/gp13 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD13/gp13 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD13/gp13 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp13 for initiating signal transmission. CD13/gp13 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD13/gp13 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
全称
interleukin 6 signal transducer
参考文献
  • Hibi, et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
  • Kim H, et al. (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
  • Giordano V, et al. (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.
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