HER3 / ERBB3 Protein

HER3 / ERBB3 Protein Overview

HER3 / ERBB3 reagents

Kraus et al. (1989) detected a DNA fragment related to but distinct from epidermal growth factor receptor (EGFR; 131550) and ERBB2 (164870). cDNA cloning showed a predicted 148-kD transmembrane polypeptide with structural features identifying it as a member of the ERBB gene family, prompting the designation ERBB3. Markedly elevated ERBB3 mRNA levels were demonstrated in certain human mammary tumor cell lines, suggesting that it may play a role in some human malignancies just as does EGFR (also called ERBB1).

HER3 / ERBB3 protein family

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.

HER3 / ERBB3 protein name

Recommended name
Receptor tyrosine-protein kinase erbB-3
Aliases
HER3, human epidermal growth factor receptor 3
Alternative name
Proto-oncogene-like protein c-ErbB-3 Tyrosine kinase-type cell surface receptor HER3

HER3 / ERBB3 Gene family protein

Erb-b2 receptor tyrosine kinases

HER3 / ERBB3 Protein Sequence

Species Human HER3 / ERBB3 protein
Length 1342
Mass (Da) 148098
Sequence Human HER3 / ERBB3 protein sequence
Species Mouse HER3 / ERBB3 protein
Length 1339
Mass (Da) 147613
Sequence Mouse HER3 / ERBB3 protein sequence
Species Rat HER3 / ERBB3 protein
Length 1339
Mass (Da) 147546
Sequence Rat HER3 / ERBB3 protein sequence

HER3 / ERBB3 Protein Molecular Weight & PI

Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 20-1342 Receptor tyrosine-protein kinase erbB-3.

Molecular weight (Da)

146070.77

Theoretical pI

6.07

HER3 / ERBB3 Protein Structure

Crystal Structure of sErbB3-Fab3379 Complex
Deposited
2015-07-25   Released:  2015-10-14
Deposition Author(s)
Lee, S., Schlessinger, J.
Organism(s)
Homo sapiens
Expression System
Escherichia coli BL21(DE3), Spodoptera frugiperda
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
3.2000 Å
R-Value Free
0.278
R-Value Work
0.252
5CUS From PDB

Human HER3 / ERBB3 protein Secondary structure

HER3 / ERBB3 Protein Interaction

Recombinant HER3 / ERBB3 Protein Feature

HER3 / ERBB3 Protein, Human, Recombinant (Fc Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measure by its ability to bind with human NRG1-β1 in a functional ELISA.

Recombinant HER3 / ERBB3 protein citations

Title
Size and conformational features of ErbB2 and ErbB3 receptors: a TEM and DLS comparative study
Year
2011
Author
E Vicente-Alique, R Núñez-Ramírez, JF Vega…
Journal
Eur Biophys J
Title
Development and characterization of small bispecific albumin-binding domains with high affinity for ErbB3
Year
2013
Author
Nilvebrant, J;Astrand, M;Löfblom, J;Hober, S;
Journal
Cell. Mol. Life Sci.
Title
Development and characterization of small bispecific albumin-binding domains with high affinity for ErbB3
Year
2013
Author
Nilvebrant, J;Astrand, M;Löfblom, J;Hober, S;
Journal
Cell. Mol. Life Sci.
Title
Inhibiting HER3-mediated tumor cell growth with affibody molecules engineered to low picomolar affinity by position-directed error-prone PCR-like diversification
Year
2013
Author
Malm, M;Kronqvist, N;Lindberg, H;Gudmundsdotter, L;Bass, T;Frejd, FY;Höidén-Guthenberg, I;Varasteh, Z;Orlova, A;Tolmachev, V;Ståhl, S;Löfblom, J;
Journal
PLoS ONE
Title
In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin-binding therapeutic affibody construct
Year
2017
Author
Bass, TZ;Rosestedt, M;Mitran, B;Frejd, FY;Löfblom, J;Tolmachev, V;Ståhl, S;Orlova, A;
Journal
Sci Rep
Title
Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4)
Year
2017
Author
Broughton, MN;Westgaard, A;Paus, E;Øijordsbakken, M;Henanger, KJ;Naume, B;Bjøro, T;
Journal
Tumour Biol.
Title
Tumor detection using magnetosome nanoparticles functionalized with a newly screened EGFR/HER2 targeting peptide
Year
2017
Author
Xiang, Z;Yang, X;Xu, J;Lai, W;Wang, Z;Hu, Z;Tian, J;
Journal
Biomaterials
Title
Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab
Year
2018
Author
Orlova, A;Bass, TZ;Rinne, SS;Leitao, CD;Rosestedt, M;Atterby, C;Gudmundsdotter, L;Frejd, FY;Löfblom, J;Tolmachev, V;Ståhl, S;
Journal
Mol. Pharm.
Title
Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab
Year
2018
Author
Orlova, A;Bass, TZ;Rinne, SS;Leitao, CD;Rosestedt, M;Atterby, C;Gudmundsdotter, L;Frejd, FY;Löfblom, J;Tolmachev, V;Ståhl, S;
Journal
Mol. Pharm.
Title
Site-Specific Photoconjugation of Beta-Lactamase Fragments to Monoclonal Antibodies Enables Sensitive Analyte Detection via Split-Enzyme Complementation
Year
2018
Author
Yu, F;Alesand, V;Nygren, PÅ;
Journal
Biotechnol J
Title
Optimization of HER3 expression imaging using affibody molecules: Influence of chelator for labeling with indium-111
Year
2019
Author
Rinne, SS;Leitao, CD;Mitran, B;Bass, TZ;Andersson, KG;Tolmachev, V;Ståhl, S;Löfblom, J;Orlova, A;
Journal
Sci Rep
Title
Optimization of HER3 expression imaging using affibody molecules: Influence of chelator for labeling with indium-111
Year
2019
Author
Rinne, SS;Leitao, CD;Mitran, B;Bass, TZ;Andersson, KG;Tolmachev, V;Ståhl, S;Löfblom, J;Orlova, A;
Journal
Sci Rep
Title
Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of 68Ga-Labeled Tracers
Year
2019
Author
Dahlsson Leitao, C;Rinne, SS;Mitran, B;Vorobyeva, A;Andersson, KG;Tolmachev, V;Ståhl, S;Löfblom, J;Orlova, A;
Journal
Int J Mol Sci

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