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 UBASH3B / Sts1 / TULA-2  蛋白

All UBASH3B  Reagents

UBASH3B / Sts1 / TULA-2
表达宿主: E. coli  
13868-H07E-20
13868-H07E-100
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UBASH3B / Sts1 / TULA-2 相关研究领域

UBASH3B / Sts1 / TULA-2 相关信号通路

    UBASH3B / Sts1 / TULA-2 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    UBASH3B / Sts1 / TULA-2 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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    UBASH3B / Sts1 / TULA-2 概述&蛋白信息

    UBASH3B / Sts1 / TULA-2 研究背景

    基因概述: UBASH3B encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. UBASH3B was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    催化活性: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000269|PubMed:17880946}.
    亚单位结构: Homodimer (By similarity). Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins. {ECO:0000250, ECO:0000269|PubMed:15159412}.
    亚细胞定位: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000305}.
    相似的序列: Contains 1 SH3 domain. {ECO:0000255|PROSITE-ProRule:PRU00192}.; Contains 1 UBA domain. {ECO:0000255|PROSITE-ProRule:PRU00212}.
    General information above from UniProt

    UBASH3B contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. UBASH3B was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. UBASH3B interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. It promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. UBASH3B exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

    UBASH3B / Sts1 / TULA-2 别称

    p70,STS1,STS-1,TULA2,TULA-2, [homo-sapiens]
    ubiquitin associated and SH3 domain containing B,UBASH3B,STS-1,STS1,TULA-2,p70,Cbl-interacting protein Sts-1,SH3 domain-containing 70 kDa protein,suppressor of T-cell receptor signaling 1,nm23-phosphorylated unknown substrate,T-cell ubiquitin ligand 2,cbl-interacting protein p70,tyrosine-protein phosphatase STS1/TULA2,ubiquitin-associated and SH3 domain-containing protein B, [human]
    ubiquitin associated and SH3 domain containing, B,Ubash3b,2810457I06Rik,BB125008,TULA-2,p70,STS-1,T-cell ubiquitin ligand 2,cbl-interacting protein p70,suppressor of T-cell receptor signaling 1,tyrosine-protein phosphatase STS1/TULA2,ubiquitin-associated and SH3 domain-containing protein B, [mouse]
    p70,TULA-2,BB125008,2810457I06Rik, [mus-musculus]

    UBASH3B / Sts1 / TULA-2 相关文献

  • Maruyama K, et al. (1994) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 138(1-2):171-4.
  • Carpino N, et al. (2002) Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. Mol Cell Biol. 22(21):7491-500.
  • Nagase T, et al. (2002) Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. DNA Res. 8(6):319-27.
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