CEACAM1 Protein, Human, Recombinant (His & Fc Tag)

1/1
Price:
Size:
Number:

CEACAM1 Protein, Human, Recombinant (His & Fc Tag): 产品信息

纯度
> 90 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
生物活性
Testing in progress
蛋白构建
A DNA sequence encoding the extracellular domain of human CEACAM1 (NP_001020083.1) (Met 1-Gly 428) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
表达宿主
HEK293 Cells
种属
Human
预测 N 端
Gln 35
分子量
The secreted recombinant human CEACAM1/Fc chimera is a disulfide-linked homodimer. The reduced monomer comprises 642 amino acids and predicts a molecular mass of 71 kDa.
缓冲液
Lyophilized from sterile 100 mM Glycine, 500 mM NaCl, 5 % Glycerol, 50 mM Arg Hcl, 50 mM Glu, 0.01 % tween 20, pH 5.0.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CEACAM1 Protein, Human, Recombinant (His & Fc Tag): 图片

CEACAM1 Protein, Human, Recombinant (His & Fc Tag): 别称

BGP Protein, Human; BGP1 Protein, Human; BGPI Protein, Human; CD66a Protein, Human; CEACAM‑1 Protein, Human

CEACAM1 背景信息

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
全称
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
参考文献
  • Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46.
  • Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82.
  • Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.
  • Fusobacterium spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF
    Author
    Brewer, M;Dymock, D;Brady, R;Singer, B;Virji, M;Hill, D;
    Year
    2019
    Journal
    Journal of Oral Microbiology
    Application
    binding
添加购物车成功! 添加购物车失败!请再次尝试 正在更新购物车,请稍后