Anti-IL17RA Antibody (APC)

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Anti-IL17RA Antibody (APC) (Mouse Monoclonal 抗体) 产品信息

产品名称
Anti-IL17RA Antibody (APC)
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human IL17RA
免疫原
Recombinant Human IL17RA/IL-17RA/CD217 Protein (Catalog#10895-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL17RA/IL-17RA/CD217 (rh IL17RA/IL-17RA/CD217; Catalog#10895-H08H; NP_055154.3; Met1-Trp320) and conjugated with APC under optimum conditions, the unreacted APC was removed.
来源
Monoclonal Mouse IgG1 Clone #06
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
APC
浓度
5 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-IL17RA Antibody (APC) (Mouse Monoclonal 抗体) 图片

Flow cytometric analysis of Human IL17RA(CD217) expression on human whole blood granulocytes. Cells were stained with APC-conjugated anti-Human IL17RA(CD217). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes.

Anti-IL17RA Antibody (APC): 别称

Anti-CANDF5 Antibody; Anti-CD217 Antibody; Anti-CDw217 Antibody; Anti-hIL-17R Antibody; Anti-IL-17RA Antibody; Anti-IL17R Antibody

IL17RA 背景信息

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
全称
interleukin 17 receptor A
参考文献
  • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
  • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
  • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.
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