IL-23 P19 / IL23A (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All IL-23 P19 / IL23A reagents are produced in house and quality controlled, including 2 IL-23 P19 / IL23A Antibody, 62 IL-23 P19 / IL23A Gene, 2 IL-23 P19 / IL23A Lysate, 2 IL-23 P19 / IL23A Protein, 3 IL-23 P19 / IL23A qPCR. All IL-23 P19 / IL23A reagents are ready to use.

IL-23 P19 / IL23A 分子背景

IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.

IL-23 P19 / IL23A 参考文献

  • Ye X, Zhang L, Wang H, et al. The Role of IL-23/Th17 Pathway in Patients with Primary Immune Thrombocytopenia. Kuwana M, ed. PLoS ONE. 2015;10(1):e0117704.