Anti-gp130 / IL6ST Antibody (PE)

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Anti-gp130 / IL6ST Antibody (PE) (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-gp130 / IL6ST Antibody (PE)
经验证的应用
FCM
交叉反应
Reacts with: Mouse
特异性
Mouse gp130 / IL6ST
免疫原
Recombinant Mouse IL6ST/gp130/CD130 Protein (Catalog#50135-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL6ST/gp130/CD130 (rM IL6ST/gp130/CD130; Catalog#50135-M08H; NP_034690.3; Met1-Glu617) and conjugated with PE under optimum conditions, the unreacted PE was removed.
来源
Monoclonal Rabbit IgG Clone #022
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
PE
浓度
5 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-gp130 / IL6ST Antibody (PE) (Rabbit Monoclonal 抗体) 图片

Flow cytometric analysis of Mouse IL6ST(CD130) expression on BABL/c splenocytes. Cells were stained with PE-conjugated anti-Mouse IL6ST(CD130) and FITC-conjugated anti-Mouse CD3. The dot plots were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-gp130 / IL6ST Antibody (PE): 别称

Anti-5133400A03Rik Antibody; Anti-AA389424 Antibody; Anti-BB405851 Antibody; Anti-CD130 Antibody; Anti-D13Ertd699e Antibody; Anti-gp130 Antibody

gp130 / IL6ST 背景信息

Glycoprotein 13 (also known as gp13, IL6ST, IL6-beta or CD13) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD13/gp13 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD13/gp13 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD13/gp13 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp13 for initiating signal transmission. CD13/gp13 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD13/gp13 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
全称
interleukin 6 signal transducer
参考文献
  • Hibi, et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
  • Kim H, et al. (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
  • Giordano V, et al. (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.
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