IP-10/CXCL10 ELISA Kit, Human

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IP-10/CXCL10 ELISA Kit, Human: 产品信息

产品名称
IP-10/CXCL10 ELISA Kit, Human
检测原理
Solid Phase Sandwich ELISA (quantitative)
偶联物
HRP
检测样品
Serum
灵敏度
1.68 pg/mL
线性范围
3.91-250 pg/mL
特异性
Recognizes both recombinant and natural Human IP-10/CXCL10
干扰
Preparations of the following factors at 50 ng/mL in a mid-range recombinant Human CXCL10 control were assayed for interference. No significant interference was observed.
产品概述
This IP-10/CXCL10 ELISA Kit, Human is an enzyme-linked immunosorbent assay for the quantitative measurement of Human IP-10/CXCL10 protein in Serum . It contains recombinant Human IP-10/CXCL10, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
运输方式
This ELISA Kit is shipped at ambient temperature.
储存条件
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA

IP-10/CXCL10 ELISA Kit, Human: 图片

This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
This assay recognizes both recombinant and natural Human CXCL10. The factors listed below were prepared at 50 ng/mL in dilution buffer and assayed for cross-reactivity. No cross-reactivity was observed.

IP-10/CXCL10 ELISA Kit, Human: 别称

C7 ELISA Kit, Human; crg-2 ELISA Kit, Human; gIP-10 ELISA Kit, Human; IFI10 ELISA Kit, Human; INP10 ELISA Kit, Human; IP-10 ELISA Kit, Human; mob-1 ELISA Kit, Human; SCYB10 ELISA Kit, Human

IP-10/CXCL10 背景信息

(C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10/IP-10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10/IP-10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type 1 diabetes, autoimmune thyroiditis, Graves' disease and ophthalmopathy), or systemic (such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, mixed cryoglobulinemia, Sjögren syndrome, or systemic sclerosis). CXCL10/IP-10 is secreted by several cell types including endothelial cells, fibroblasts, keratinocytes, thyrocytes, preadipocytes, etc. Determination of high level of CXCL10/IP-10 in peripheral fluids is therefore a marker of host immune response.
全称
chemokine (C-X-C motif) ligand 10
参考文献
  • O'Donovan N, et al. (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84(1-2):39-42.
  • Swaminathan GJ, et al. (2003) Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure. 11(5):521-32.
  • Booth V, et al. (2002) The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry. 41(33):10418-25.
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