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MAPK11  蛋白,抗体,试剂盒,cDNA克隆

MAPK11 相关研究领域

MAPK11 相关蛋白、抗体、cDNA基因、ELISA试剂盒

MAPK11 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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MAPK11 概述&蛋白信息

MAPK11 研究背景

催化活性: ATP + a protein = ADP + a phosphoprotein.
辅因子: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
酶调控: ENZYME REGULATION: Activated by phosphorylation on threonine and tyrosine by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 induced by environmental stress. HDAC3 interacts directly and selectively with MAPK11 to repress ATF2 transcriptional activity, and regulate TNF gene expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related compounds. {ECO:0000269|PubMed:11359773, ECO:0000269|PubMed:15356147, ECO:0000269|PubMed:9218798, ECO:0000269|PubMed:9430721}.
亚单位结构: Interacts with HDAC3 and DUSP16. {ECO:0000269|PubMed:11359773, ECO:0000269|PubMed:15356147, ECO:0000269|PubMed:19622861}.
结构域: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
亚细胞定位: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
组织特异性: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
翻译后修饰: Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6, which activates the enzyme. {ECO:0000269|PubMed:15356147}.
相似的序列: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

MAPK11 别称

P38B,SAPK2,p38-2,PRKM11,SAPK2B,p38Beta,P38BETA2, [homo-sapiens]
P38b,Sapk2,p38-2,Prkm11,Sapk2b,p38beta,p38beta2, [mus-musculus]

MAPK11 相关文献