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小鼠 Protein HC/Bikunin  基因

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Protein HC/Bikunin

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Protein HC/Bikunin 相关研究领域

Protein HC/Bikunin 相关信号通路

    Protein HC/Bikunin 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    Protein HC/Bikunin 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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    Protein HC/Bikunin 概述&蛋白信息

    Protein HC/Bikunin 研究背景

    亚单位结构: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin. Alpha-1-microglobulin occurs as a monomer and also in complexes with IgA and albumin. Alpha-1-microglobulin interacts with FN1. Trypstatin is a monomer and also occurs as a complex with tryptase in mast cells (By similarity). Alpha-1-microglobulin and bikunin interact (via SH3 domain) with HEV ORF3 protein. {ECO:0000250, ECO:0000269|PubMed:15037615, ECO:0000269|PubMed:16140784}.
    亚细胞定位: Secreted.
    组织特异性: Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin inhibitor is present in plasma and urine.
    翻译后修饰: The precursor is proteolytically processed into separately functioning proteins.; 3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.; Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate. {ECO:0000250}.; N- and O-glycosylated. N-glycan heterogeneity at Asn-115: Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor). N-glycan at Asn-250: Hex5HexNAc4. O-linkage of the glycosaminoglycan, chondroitin sulfate, at Ser-215 allows cross-linking between the three polypeptide chains. {ECO:0000269|PubMed:1694784, ECO:0000269|PubMed:1898736, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:6171497, ECO:0000269|PubMed:7682553}.
    相似的序列: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. {ECO:0000305}.; Contains 2 BPTI/Kunitz inhibitor domains. {ECO:0000255|PROSITE-ProRule:PRU00031}.
    General information above from UniProt

    Protein HC/Bikunin 别称

    A1M,HCP,ITI,UTI,EDC1,HI30,ITIL,IATIL,ITILC, [homo-sapiens]
    alpha-1-microglobulin/bikunin precursor,AMBP,A1M,EDC1,HI30,IATIL,ITI,ITIL,ITILC,UTI,bikunin,complex-forming glycoprotein heterogeneous in charge,growth-inhibiting protein 19,inter-alpha-trypsin inhibitor light chain,protein AMBP,protein HC,trypstatin,uristatin,uronic-acid-rich protein,HCP, [human]
    alpha 1 microglobulin/bikunin,Ambp,RP23-6H1.3,AI194774,ASPI,HI-30,Intin4,Itil,UTI,Urinary Trypsin Inhibitor,polyprotein,protein AMBP,ulinastatin, [mouse]
    UTI,ASPI,Itil,HI-30,Intin4,AI194774, [mus-musculus]

    Protein HC/Bikunin 相关文献