Text Size:AAA

小鼠 interleukin-20  抗体

All IL20 Reagents

interleukin-20
反应性: Mouse  
应用 : WB  IP  
100463-T36-50
100463-T36-200
100463-T36-100
50 µg 
200 µg 
100 µg 
Add to Cart
  • Slide 1
  • Slide 1

Browse interleukin-20 Products by

interleukin-20 相关研究领域

interleukin-20 相关信号通路

    interleukin-20 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    interleukin-20 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    Featured Reagent Products

    interleukin-20 概述&蛋白信息

    interleukin-20 相关资讯

    interleukin-20 研究背景

    基因概述: The protein encoded by IL20 gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    亚单位结构: Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB. {ECO:0000269|PubMed:22802649}.
    亚细胞定位: Secreted.
    组织特异性: Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only. {ECO:0000269|PubMed:16908179}.
    诱导: Up-regulated by UV-B irradiation in epithelial keratinocytes. {ECO:0000269|PubMed:16709143}.
    相似的序列: Belongs to the IL-10 family. {ECO:0000305}.
    General information above from UniProt

    IL20/Interleukin-20 belongs to the IL-10 family. It is a cytokine structurally related to interleukin 10. IL20/Interleukin-20 can be detected in skin, trachea, and other tissues. It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells.It has been shown that interleukin-20 transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. It may be involved in epidermal function and psoriasis. It also regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL20/Interleukin-20 also causes cell expansion of multipotential hematopoietic progenitor cells. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

    interleukin-20 别称

    IL-20,IL10D,ZCYTO10, [homo-sapiens]
    cytokine Zcyto10,four alpha helix cytokine,IL10D,IL-20,interleukin-20,MGC96907,UNQ852/PRO1801,ZCYTO10, [human]
    cytokine Zcyto10,four alpha helix cytokine ZCYTO10,four helix bundle cytokine 10,IL-20,interleukin-20,MGC130536,Zcyto10, [mouse]
    Zcyto10, [mus-musculus]

    interleukin-20 相关文献

  • Chen XY, et al. (2011) The association between the IL-20-1723CG allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population. Dermatology. 222(1):24-30.
  • Baird AM, et al. (2011) IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF. Eur J Cancer. 47(12):1908-18.
  • Logsdon NJ, et al. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 1):89-92.
  • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”