Receptors

Receptors classification

Receptors by Drug Target

Cytokine & Growth Factor Receptors

Interleukin & Interleukin Receptor

IL-1A
IL-1R1
IL-1R2
IL-1RAcP
IL-1B
IL-1R1
IL-1R2
IL-1RAcP
IL-1RA
IL-1R1
IL-1R2
IL-2
IL-2Rα
IL-2Rβ
IL-2Rγ
IL-3
IL-3Rα
CSF2RB
IL-4
IL-4R
IL-2Rγ
IL-13Rα1
IL-5
IL-5Rα
CSF2RB
IL-6
IL-6Rα
gp130
IL-7
IL-7Rα
IL-2Rγ
IL-8/CXCL8
CXCR1
CXCR2
IL-9
IL-9R
IL-2Rγ
IL-10
IL-10Rα
IL-10Rβ
IL-11
IL-11Rα
gp130
IL-12A
IL-12Rβ1
IL-12Rβ2
IL-12B
IL-12Rβ1
IL-12Rβ2
IL-13
IL-13Rα1
IL-13Rα2
IL-4R
IL-14/TXLNA
unknown
IL-15
IL-15Rα
IL-2Rβ
IL-2Rγ
IL-16
CD4
CD9
IL-17A
IL-17RA
IL-17RC
IL-17RD
IL-17B
IL-17RB
IL-17C
IL-17RA
IL-17RE
IL-17D
unknown
IL-17F
IL-17RA
IL-17RC
IL-18
IL-18Rα
IL-18RAcP
IL18BP / IL18BPa
IL-19
IL-20Rα
IL-20Rβ
IL-20
IL-20Rα
IL-20Rβ
IL-22Rα1
IL-21
IL-21R
IL-2Rγ
IL-22
IL-22Rα1
IL-22Rα2
IL-10Rβ
IL-23
IL-12Rβ1
IL-23R
IL-24
IL-20Rα
IL-20Rβ
IL-22Rα1
IL-25/IL-17E
IL-17RA
IL-17RB
IL-26
IL-10Rβ
IL-20Rα
IL-27/IL-30
IL-27Rα
gp130
IL-28A
IL-28RA
IL-10Rβ
IL-28B
IL-28RA
IL-10Rβ
IL-29
IL-28RA
IL-10Rβ
IL-31
IL-31Rα
OSMR
IL-32
PR3     STAT3
PKCε     Paxillin
PKCδ
IL-33
IL-1R1
IL-1R2
IL-1RAcP
IL-34
IL-1R1
IL-1R2
IL-1RAcP
IL-35
IL-12Rβ2
gp130
IL-36A
IL-1RL2
IL-1RAcP
IL-36B
IL-1RL2
IL-1RAcP
IL-36G
IL-1RL2
IL-1RAcP
IL-36RA
IL-1RL2
IL-1RAcP
IL-37
IL18R1
IL18BP / IL18BPa
IL-38/IL1F10
IL1R1/IL-1R1
IL1RL2/IL1RRP2

TNF & TNF Receptor

TNFRSF1A
TNF-alpha
TNFRSF1B
TNF-alpha
LTBR
TNF-C
TNFRSF4
OX40L
CD40
CD154
TNFRSF6B
FasL
LIGHT
TL1A
CD27
CD70
Siva
TNFRSF8
CD153
TNFRSF9
4-1BB ligand
TNFRSF10A
TRAIL
TNFRSF10C
TRAIL
TNFRSF10C
TRAIL
TNFRSF10D
TRAIL
TNFRSF11A
RANKL
TNFRSF11B
RANKL
TNFRSF12A
TWEAK
TNFRSF13B
APRIL
BAFF
CAMLG
TNFRSF13C
BAFF
TNFRSF14
LIGHT
NGFR
NGF
BDNF
NT-3     NT-4
TNFRSF17
BAFF
TNFRSF18
GITR ligand
TNFRSF19
unknown
FAS
TNF-alpha
BAFF-R
BCMA     TACI
TNFRSF21
unknown
TNFRSF25
TL1A
EDA2R
EDA-A2

Chemokine & Chemokine Receptor

CCL1
CCR8
CCL2
CCR2
CCL3
CCR1
CCL4
CCR1
CCR5
CCL5
CCR5
CCL6
CCR1
CCL7
CCR2
CCL8
CCR1
CCR2
CCR5
CCL9
CCR1
CCL11
CCR2
CCR3
CCR5
CCL12
CXCR4
CCL13
CCR2
CCR3
CCR5
CCL14
CCR1
CCL15
CCR2
CCR5
CCL16
CCR1
CCR2
CCR5     CCR8
CCL17
CCR4
CCL18
CCR8
DARC
PITPNM3     GPR30
CCL19
CCR7
CCL20
CCR6
CCL21
CCR7
CCL22
CCR4
CCL23
CCR1
CCL24
CCR3
CCL25
CCR9
CCL26
CCR3
CCL27
CCR9
CCL28
CCR3
CCR10
CXCL1
CXCR2
CXCL2
CXCR2
CXCL3
CXCR2
CXCL4
CXCR3
CXCL5
CXCR2
CXCL6
CXCR1
CXCR2
CXCL7
CXCR2
CXCL8
CXCR1
CXCR2
CXCL9
CXCR3
CXCL10
CXCR3
CXCL11
CXCR3
CXCR7
CXCL12
CXCR4
CXCR7
CXCL13
CXCR5
CXCL14
CXCR4
CXCL15
unknown
CXCL16
CXCR6
CXCL17
CXCR8
XCL1
XCR1
XCL2
XCR1
CX3CL1
CX3CR1

Most popular GPCRs as Drug target

ACKR3 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA2A ADRB2 AGTR1 AGTR2 AVPR1A AVPR2 BDKRB1 BDKRB2 C5AR1 C5AR2 CALCR CCR1 CCR2 CCR4 CCR5 CCR6 CCR9 CHRM2 CHRM4 CHRM5 CNR1 CX3CR1 CXCR4 CXCR5 CYSLTR1 DRD1 DRD2 DRD5 EDNRA EDNRB F2R F2RL1 F2RL3 FFAR1 FSHR FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD9 GLP1R GLP2R GPR180 GPR6 GRM2 HCRTR2 HTR2A HTR2B HTR4 HTR5A HTR6 OPRD1 OPRK1 P2RY12 P2RY2 PTAFR PTGER1 PTGIR PTH1R RXFP2 S1PR1 SSTR2 TACR2 TBXA2R TSHR VIPR1 VIPR2

Receptors Reagent Products

Receptors by Species

Receptors by Differentiation Cells

Receptors by Functions

Receptors Background

Receptors are proteins, usually cell surface receptors, which bind to ligands and cause responses in the immune system. Receptors can be found in various immune cells like B cells, T cells, NK cells, monocytes and stem cells. Receptors allow the cells to recognize specific ligands and to receive extracellular messages. They can be classified into five families: 1) receptors for lipidic or lipophilic ligands; 2) the seven transmembrane receptors which mediate their messages by transduction through the activation of G-proteins, effectors and second messengers to amplify the response; 3) receptors which present an enzymatic activity on their transmembrane domains; 4) channel-receptors, transmembrane oligomeric molecules which let ions flow into the cell and 5) receptors which role is to internalize ligands, whatever their various functions.

In addition, receptors play a critical role in functions such as cell activation, cell adhesion and signaling pathways. For example, cell activation including T cells, dendritic cells, B cells, granulocytes and NK cells, is an important process in innate and adaptive immune system. Receptors on the surface of these cells help complete whole cell activation process. The innate immunity receptors that recognize pathogens also have an important role in signaling for the induced responses responsible for local inflammation, the recruitment of new effector cells, the containment of local infection, and the initiation of an adaptive immune response.

Receptors References

1. Feger, J., Gil-Falgon, S., & Lamaze, C. (1994). Cell receptors: definition, mechanisms and regulation of receptor-mediated endocytosis. Cellular and molecular biology (Noisy-le-Grand, France), 40(8), 1039-1061.

2. Akira, S., Uematsu, S., & Takeuchi, O. (2006). Pathogen recognition and innate immunity. Cell, 124(4), 783-801.