Reg3A Protein, Human, Recombinant (His Tag)

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Reg3A Protein, Human, Recombinant (His Tag): 产品信息

纯度
> 97 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
生物活性
Testing in progress
蛋白构建
A DNA sequence encoding the human REG3A (Q06141-1) (Met 1-Asp 175) precursor was fused with a polyhistidine tag at the C-terminus.
NCBI Reference No.
表达宿主
HEK293 Cells
种属
Human
预测 N 端
Glu 27
分子量
The recombinant human REG3A consists of 160 amino acids after removal of the signal peptide and has a predicted molecular mass of 18 kDa as estimated in SDS-PAGE under reducing conditions.
缓冲液
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Reg3A Protein, Human, Recombinant (His Tag): 图片

Reg3A Protein, Human, Recombinant (His Tag): 别称

HIP Protein, Human; HIP/PAP Protein, Human; INGAP Protein, Human; PAP Protein, Human; PAP-H Protein, Human; PAP1 Protein, Human; PBCGF Protein, Human; REG-III Protein, Human; REG3 Protein, Human; REG3A Protein, Human; REG3V Protein, Human

Reg3A 背景信息

Regenerating islet-derived protein 3-alpha, also known as Regenerating islet-derived protein III-alpha, REG-3-alpha, REG3A, and HIP, is secreted protein which contains one C-type lectin domain. REG3A is constitutively expressed in intestine, and is a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It is overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. REG3A and REG1A proteins are both involved in liver and pancreatic regeneration and proliferation. REG3A is also a stress protein involved in the control of bacterial proliferation. REG3A is down-regulated in most primary human gastric cancer cells, and might be useful in the diagnosis of gastric cancer. Additionally, REG3A is a target of beta-catenin signaling in Huh7 hepatoma cells. The REG1A and REG3A are downstream targets of the Wnt pathway during liver tumorigenesis.
全称
regenerating family member 3 alpha
参考文献
  • Cavard C, et al. (2006) Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with beta-catenin mutations. Oncogene. 25(4): 599-608.
  • Choi B, et al. (2007) Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas. Exp Mol Med. 39(6): 796-804.
  • SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer
    Author
    Wang, J;Zhou, H;Han, Y;Liu, X;Wang, M;Wang, X;Yin, G;Li, X;Xiang, M;
    Year
    2014
    Journal
    J. Mol. Med.
    Application
    cell-based
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