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ACVR1 Protein

ACVR1 Protein Overview

ACVR1 reagents

Activins are members of a family of polypeptide growth factors that also includes also the transforming growth factors-beta (190180, 190220, 190230), mullerian duct-inhibiting substance, and several bone morphogenetic proteins. Although activins were discovered by virtue of their capacity to stimulate the production of follicle-stimulating hormone (FSH; 136530) by the pituitary gland and inhibins were initially characterized as FSH inhibitors, activins and inhibins are dimeric proteins that share a common subunit. There are 3 activins (A, B, and A-B), comprising different combinations of 2 closely related beta subunits (beta-A/beta-A; beta-B/beta-B; and beta-A/beta-B, respectively) and 2 inhibins (A and B), consisting of 1 beta-subunit and an inhibin-specific alpha subunit (alpha/beta-A and alpha/beta-B). Activins impinge on a much broader spectrum of cells than do inhibins; however, in those systems in which both proteins are functional, they have opposing biologic effects (summary by Mathews and Vale, 1991).

ACVR1 protein family

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

ACVR1 protein name

Recommended name
Activin receptor type-1
Aliases
ACVR1A, ALK2, SKR1
Alternative name
Activin receptor type I ACTR-I Activin receptor-like kinase 2 ALK-2 Serine/threonine-protein kinase receptor R1 SKR1 TGF-B superfamily receptor type I TSR-I

ACVR1 Gene family protein

ACVR1 Protein Sequence

Species Human ACVR1 protein
Length 509
Mass (Da) 57153
Sequence Human ACVR1 protein sequence
Species Mouse ACVR1 protein
Length 509
Mass (Da) 57226
Sequence Mouse ACVR1 protein sequence
Species Rat ACVR1 protein
Length 509
Mass (Da) 57195
Sequence Rat ACVR1 protein sequence

ACVR1 Protein Molecular Weight & PI

Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 21-509 Activin receptor type-1.

Molecular weight (Da)

55074.2

Theoretical pI

7.45

ACVR1 Protein Structure

Crystal structure of the ACVR1 kinase domain in complex with LDN-193189
Deposited
2010-12-24   Released:  2011-02-09
Deposition Author(s)
Chaikuad, A., Sanvitale, C., Cooper, C.D.O., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Allerston, C.K., Krojer, T., Vollmar, M., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Organism(s)
Homo sapiens
Expression System
Spodoptera frugiperda
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
1.8200 Å
R-Value Free
0.219
R-Value Work
0.163
3Q4U From PDB

Human ACVR1 protein Secondary structure

ACVR1 Protein Interaction

Recombinant ACVR1 Protein Feature

ACVR1 Protein, Human, Recombinant (His Tag)

High Purity
> 93 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Kinase activity untested

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