CD33: CD33 Protein | CD33 Antibody

CD33 Gene family

CD33 Background

Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.

Reference for CD33

  • Simmons D, et al. (1988) Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. J Immunol. 141(8): 2797-800.
  • Ulyanova T, et al. (1999) The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur J Immunol. 29(11): 3440-9.
  • Freeman SD, et al. (1995) Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood. 85(8): 2005-12.

CD33 Protein

CD33 protein function

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). {ECO:0000269|PubMed:10556798, ECO:0000269|PubMed:11320212}.

CD33 protein expression

Tissue specificity

Monocytic/myeloid lineage cells.

CD33 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    364.00
  • Mass (Da)
    39.00

CD33 Antibody

There are 19 CD33 antibodies which are validated in multiple tissues with various applications, including ELISA, FCM, WB, IP. There are 8 CD33 antibody for ELISA, 13 CD33 antibody for FCM, 1 CD33 antibody for WB, 1 CD33 antibody for IP. Among all these CD33 antibodies, there are 8 anti-CD33 mouse monoclonal antibodies , 5 anti-CD33 rabbit monoclonal antibodies , 6 anti-CD33 rabbit polyclonal antibodies . All the CD33 anbodies are produced in house and all are in stock. CD33 antibody customerized service is available.

CD33 Gene

CD33 gene / cDNA is a protein-coding gene which located on 19q13.41. The CD33 gene is conserved in chimpanzee, Rhesus monkey, dog, and cow.25 organisms have orthologs with human gene CD33.