Contactin-1 Protein

Contactin-1 Protein Overview

Contactin-1 reagents

Using immunoprecipitation and fluorescence microscopy, Hu et al. (2003) identified mouse F3 as a physiologic ligand and activator of Notch (190198). Upon activation by F3, Notch signals through Dtx1 (602582), which leads to oligodendrocyte maturation via upregulation of certain myelin-related proteins. Thus, Hu et al. (2003) concluded that Notch does not solely function to inhibit oligodendrocyte precursor differentiation to mature cells, and they suggested that it may be useful in promoting remyelination in degenerative diseases. Compton et al. (2008) found low levels of CNTN1 expression in normal human and mouse skeletal muscle that was restricted to the neuromuscular junction (NMJ). In patients with secondary dystroglycanopathies, such as Fukuyama muscular dystrophy (253800) and muscle-eye-brain disease (253280), CNTN1 was not restricted to the NMJ, but was also found in the sarcolemmal membrane. In contrast, in either denervated skeletal or skeletal muscle of patients with generalized dystrophic Duchenne muscular dystrophy (310200), sarcolemmal expression of CNTN1 was not observed. These findings suggested that mistargeting of CNTN1 to the sarcolemmal membrane is associated with the loss of glycosylated membrane-bound alpha-dystroglycan (128239), not with primary dystrophic or neuropathic processes.

Contactin-1 protein family

Belongs to the immunoglobulin superfamily. Contactin family.

Contactin-1 protein name

Recommended name
Contactin-1
Aliases
F3, glycoprotein gP135, GP135
Alternative name
Glycoprotein gp135 Neural cell surface protein F3

Contactin-1 Gene family protein

Contactin-1 Protein Sequence

Species Human Contactin-1 protein
Length 1018
Mass (Da) 113320
Sequence Human Contactin-1 protein sequence
Species Mouse Contactin-1 protein
Length 1020
Mass (Da) 113388
Sequence Mouse Contactin-1 protein sequence
Species Rat Contactin-1 protein
Length 1021
Mass (Da) 113495
Sequence Rat Contactin-1 protein sequence

Contactin-1 Protein Molecular Weight & PI

Contactin-1 precursor (Glycoprotein gp135) (Neural cell surface protein F3) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 21-?993 Contactin-1.

Molecular weight (Da)

108481.4

Theoretical pI

5.58

Contactin-1 Protein Structure

PTPRZ CNTN1 complex
Deposited
2011-05-31   Released:  2011-09-28
Deposition Author(s)
Bouyain, S.
Organism(s)
Homo sapiens
Expression System
Homo sapiens, Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.2970 Å
R-Value Free
0.255
R-Value Work
0.201
3S97 From PDB

Human Contactin-1 protein Secondary structure

Contactin-1 Protein Interaction

Recombinant Contactin-1 Protein Feature

Contactin-1 Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant Contactin-1 protein citations

Title
Biomarkers of 'acute-onset'chronic inflammatory demyelinating polyneuropathy
Year
2014
Author
Y Miura, N Shahrizaila, N Yuki
Journal
Brain
Title
Specific Contactin N-glycans are implicated in Neurofascin binding and autoimmune targeting in peripheral neuropathies
Year
2014
Author
Labasque, M;Hivert, B;Nogales-Gadea, G;Querol, L;Illa, I;Faivre-Sarrailh, C;
Journal
J. Biol. Chem.
Title
Auto-antibodies to contactin-associated protein 1 (Caspr) in two patients with painful inflammatory neuropathy
Year
2016
Author
Doppler, K;Appeltshauser, L;Villmann, C;Martin, C;Peles, E;Krämer, HH;Haarmann, A;Buttmann, M;Sommer, C;
Journal
Brain
Title
Complement deposition induced by binding of anti-contactin-1 auto-antibodies is modified by immunoglobulins
Year
2017
Author
Appeltshauser, L;Weishaupt, A;Sommer, C;Doppler, K;
Journal
Exp. Neurol.
Title
Neurofascin-155 IgM autoantibodies in patients with inflammatory neuropathies
Year
2018
Author
Doppler, K;Stengel, H;Appeltshauser, L;Grosskreutz, J;Man Ng, JK;Meinl, E;Sommer, C;
Journal
J. Neurol. Neurosurg. Psychiatry

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