gp130/IL6ST: gp130/IL6ST Protein | gp130/IL6ST Antibody

gp130/IL6ST Gene family

gp130/IL6ST Background

Glycoprotein 13 (also known as gp13, IL6ST, IL6-beta or CD13) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD13/gp13 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD13/gp13 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD13/gp13 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp13 for initiating signal transmission. CD13/gp13 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD13/gp13 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

Reference for gp130/IL6ST

  • Hibi, et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
  • Kim H, et al. (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
  • Giordano V, et al. (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.

gp130/IL6ST Protein

gp130/IL6ST protein function

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:Q00560, ECO:0000269|PubMed:19915009, ECO:0000269|PubMed:2261637, ECO:0000269|PubMed:23294003}.

gp130/IL6ST protein expression

Tissue specificity

Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).

Induction

LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.

gp130/IL6ST protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    918.00
  • Mass (Da)
    103.00

gp130/IL6ST Antibody

There are 21 gp130/IL6ST antibodies which are validated in multiple tissues with various applications, including IHC-P, ICC/IF, ELISA, FCM, ELISA(Cap), ELISA(Det). There are 3 gp130/IL6ST antibody for IHC-P, 2 gp130/IL6ST antibody for ICC/IF, 11 gp130/IL6ST antibody for ELISA, 7 gp130/IL6ST antibody for FCM, 1 gp130/IL6ST antibody for ELISA(Cap), 1 gp130/IL6ST antibody for ELISA(Det). Among all these gp130/IL6ST antibodies, there are 8 anti-gp130/IL6ST rabbit polyclonal antibodies , 4 anti-gp130/IL6ST mouse monoclonal antibodies , 9 anti-gp130/IL6ST rabbit monoclonal antibodies . All the gp130/IL6ST anbodies are produced in house and all are in stock. gp130/IL6ST antibody customerized service is available.

gp130/IL6ST Gene

IL6ST gene / cDNA is a protein-coding gene which located on 5q11.2. The IL6ST gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.218 organisms have orthologs with human gene IL6ST.