gp130/IL6ST cDNA Clone: Expression and Clone Vector / Plasmid

gp130/IL6ST cDNA / Gene Overview

IL6ST gene / cDNA is a protein-coding gene which located on 5q11.2. The IL6ST gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.218 organisms have orthologs with human gene IL6ST.

gp130/IL6ST cDNA / Gene Function

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

gp130/IL6ST cDNA / Gene Sequence

LOCUS
LOCUS NM_002184 9071 bp mRNA linear PRI 15-JUL-2018
DEFINITION
Homo sapiens interleukin 6 signal transducer (IL6ST), transcript variant 1, mRNA.
ACCESSION
NM_002184
VERSION
NM_002184.3

This sequence information is just for reference only.

gp130/IL6ST Family & Reagents

gp130/IL6ST Gene family reagents (CD molecules)

Approved Symbol Reagent list
MPL
CD177
ADGRE5
KLRK1
B3gat1
CD34
NCR1
TNFRSF11A
LEPR
GYPC
Approved Symbol Reagent list
L1CAM
PECAM1
BST1
CDH1
CD209
NT5E
TNFRSF10C
IL13Ra1
MSR1
PDCD1

gp130/IL6ST Gene family reagents (Fibronectin type III domain containing)

Approved Symbol Reagent list
EPHA8
CSF3R
FLRT2
GHR
EphB4
IL12RB2
IL2RG
EphA4
IL7R
FLRT1
Approved Symbol Reagent list
CHL1
CNTN4
LIFR
ROBO4
IL20RB
EPHA1
CNTN5
LRRN3
FNDC4
EphA7

gp130/IL6ST Gene family reagents (Interleukin receptors)

Approved Symbol Reagent list
IL1RL2
IL18RAP
IL2RA
IL21R
IL7R
IL17RB
IL31RA
IL1RL1
IL5RA
IL20RB
Approved Symbol Reagent list
IL11RA
IL17RA
IL3Ra
IL9R
IL1R1
IL1RAPL1
IL27Ra
IL1R2
IL10RB
IL10RA

gp130/IL6ST cDNA / Gene Alias

  • CD130
  • GP130
  • gp130
  • oncostatin M receptor
  • Interleukin-6 receptor subunit beta

gp130/IL6ST cDNA / Gene Expression

Ubiquitous expression in placenta (RPKM 88.6), fat (RPKM 53.5) and 24 other tissues