Neuropilin-1 cDNA Clone: Expression and Clone Vector / Plasmid

Neuropilin-1 cDNA / Gene Overview

NRP1 gene / cDNA is a protein-coding gene which located on 10p11.22. The NRP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.230 organisms have orthologs with human gene NRP1.

Neuropilin-1 cDNA / Gene Function

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Neuropilin-1 cDNA / Gene Sequence

LOCUS
LOCUS NM_001024628 2478 bp mRNA linear PRI 22-JUL-2018
DEFINITION
Homo sapiens neuropilin 1 (NRP1), transcript variant 2, mRNA.
ACCESSION
NM_001024628
VERSION
NM_001024628.2

This sequence information is just for reference only.

Neuropilin-1 Family & Reagents

Gene family

Neuropilin-1 Gene family reagents (CD molecules)

Approved Symbol Reagent list
NCAM1
CLEC4M
CD81
IL13Ra2
MELTF
FGFR4
CSF2RA
CD99
CLEC12A
TNFRSF10A
Approved Symbol Reagent list
FCAMR
MME
FASLG
TNFRSF10D
CD207
IL1R1
FCER2
GYPA
CDH1
IL7R

Neuropilin-1 cDNA / Gene Alias

  • CD304
  • NRP
  • VEGF165R

Neuropilin-1 cDNA / Gene Expression

Broad expression in placenta (RPKM 53.3), fat (RPKM 49.6) and 24 other tissues

Recombinant Neuropilin-1 protein citations

Title
Neuropilin-1 (NRP-1)/GIPC1 pathway mediates glioma progression
Year
2016
Author
Zhang, G;Chen, L;Sun, K;Khan, AA;Yan, J;Liu, H;Lu, A;Gu, N;
Journal
Tumour Biol.