OTUB1 cDNA Clone: Expression and Clone Vector / Plasmid
OTUB1 cDNA / Gene Overview
OTUB1 gene / cDNA is a protein-coding gene which located on 11q13.1. The OTUB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, rat, chicken, N.crassa, and frog.171 organisms have orthologs with human gene OTUB1.
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
OTUB1 cDNA / Gene Sequence
LOCUS NM_017670 2310 bp mRNA linear PRI 23-JUN-2018
DEFINITION Homo sapiens OTU deubiquitinase, ubiquitin aldehyde binding 1 (OTUB1), transcript variant 1, mRNA.
This sequence information is just for reference only.