OTUB1 cDNA Clone: Expression and Clone Vector / Plasmid

OTUB1 cDNA / Gene Overview

OTUB1 gene / cDNA is a protein-coding gene which located on 11q13.1. The OTUB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, rat, chicken, N.crassa, and frog.171 organisms have orthologs with human gene OTUB1.

OTUB1 cDNA / Gene Function

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

OTUB1 cDNA / Gene Sequence

LOCUS
LOCUS NM_017670 2310 bp mRNA linear PRI 23-JUN-2018
DEFINITION
DEFINITION Homo sapiens OTU deubiquitinase, ubiquitin aldehyde binding 1 (OTUB1), transcript variant 1, mRNA.
ACCESSION
NM_017670
VERSION
NM_017670.2

This sequence information is just for reference only.

OTUB1 Family & Reagents

Gene family

OTUB1 Gene family reagents (OTU domain containing)

Approved Symbol Reagent list
OTUB2

OTUB1 cDNA / Gene Alias

  • FLJ20113
  • FLJ40710

OTUB1 cDNA / Gene Expression

Ubiquitous expression in brain (RPKM 29.9), placenta (RPKM 22.0) and 25 other tissues