OTUB1 Protein

OTUB1 Protein Overview

OTUB1 reagents

Otubains, such as OTB1, are deubiquitylating cysteine proteases (DUBs; see 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see 191339)-protein bond (Balakirev et al., 2003).

OTUB1 protein family

Belongs to the peptidase C65 family.

OTUB1 protein name

Recommended name
Ubiquitin thioesterase OTUB1
Aliases
FLJ20113, FLJ40710
Alternative name
Deubiquitinating enzyme OTUB1 OTU domain-containing ubiquitin aldehyde-binding protein 1 Otubain-1 Ubiquitin-specific-processing protease OTUB1

OTUB1 Gene family protein

OTU domain containing
Approved symbol Common name
OTUB2 OTUB2 protein, recombinant

OTUB1 Protein Sequence

Species Human OTUB1 protein
Length 271
Mass (Da) 31284
Sequence Human OTUB1 protein sequence
Species Mouse OTUB1 protein
Length 271
Mass (Da) 31270
Sequence Mouse OTUB1 protein sequence
Species Rat OTUB1 protein
Length 271
Mass (Da) 31270
Sequence Rat OTUB1 protein sequence

OTUB1 Protein Molecular Weight & PI

Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1) Homo sapiens (Human). Please select one of the following

The parameters have been computed for the following feature

FT CHAIN 2-271 Ubiquitin thioesterase OTUB1.

Molecular weight (Da)

31152.87

Theoretical pI

4.85

OTUB1 Protein Structure

Crystal structure of human OTUB1/UbcH5b~Ub/Ub
Deposited
2012-01-18   Released:  2012-02-22
Deposition Author(s)
Juang, Y.C., Sanches, M., Sicheri, F.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
3.2990 Å
R-Value Free
0.280
R-Value Work
0.233
4DDG From PDB

Human OTUB1 protein Secondary structure

OTUB1 Protein Interaction

Recombinant OTUB1 Protein Feature

OTUB1 Protein, Human, Recombinant (His Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
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