TGF beta 2 cDNA Clone: Expression and Clone Vector / Plasmid

TGF beta 2 cDNA / Gene Overview

TGFB2 gene / cDNA is a protein-coding gene which located on 1q41. The TGFB2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.231 organisms have orthologs with human gene TGFB2.

TGF beta 2 cDNA / Gene Function

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]

TGF beta 2 cDNA / Gene Sequence

LOCUS
LOCUS NM_003238 5932 bp mRNA linear PRI 23-JUL-2018
DEFINITION
Homo sapiens transforming growth factor beta 2 (TGFB2), transcript variant 2, mRNA.
ACCESSION
NM_003238
VERSION
NM_003238.4

This sequence information is just for reference only.

TGF beta 2 Family & Reagents

Gene family

TGF beta 2 Gene family reagents (Endogenous ligands)

Approved Symbol Reagent list
CCL26
SELPLG
GH1
LIF
XCL1
CCL22
LGALS1
ICOSLG
VIP
APP
Approved Symbol Reagent list
CD274
CALCB
CCL28
FGF6
FGF1
TGFB1
CCL20
INS
LGALS3
GHRH

TGF beta 2 cDNA / Gene Alias

  • prepro-transforming growth factor beta-2

TGF beta 2 cDNA / Gene Expression

Broad expression in prostate (RPKM 9.5), lung (RPKM 6.3) and 18 other tissues