VEGFA cDNA Clone: Expression and Clone Vector / Plasmid

VEGFA cDNA / Gene Overview

VEGFA gene / cDNA is a protein-coding gene which located on 6p21.1. The VEGFA gene is conserved in dog, cow, mouse, rat, chicken, and zebrafish.230 organisms have orthologs with human gene VEGFA.

VEGFA cDNA / Gene Function

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]

VEGFA cDNA / Gene Sequence

LOCUS
LOCUS NM_001025366 3677 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens vascular endothelial growth factor A (VEGFA), transcript variant 1, mRNA.
ACCESSION
NM_001025366
VERSION
NM_001025366.2

This sequence information is just for reference only.

VEGFA Family & Reagents

Gene family

VEGFA Gene family reagents (VEGF family)

Approved Symbol Reagent list
PGF
VEGFC
Approved Symbol Reagent list
VEGFB
VEGFD

VEGFA cDNA / Gene Alias

  • VEGF-A
  • VPF

VEGFA cDNA / Gene Expression

Broad expression in thyroid (RPKM 146.9), prostate (RPKM 69.5) and 21 other tissues

Recombinant VEGFA protein citations

Title
Barbigerone, an isoflavone, inhibits tumor angiogenesis and human non-small-cell lung cancer xenografts growth through VEGFR2 signaling pathways
Year
2012
Author
Li, X;Wang, X;Ye, H;Peng, A;Chen, L;
Journal
Cancer Chemother. Pharmacol.
Title
Immunogenicity and efficacy of a rationally designed vaccine against vascular endothelial growth factor in mouse solid tumor models
Year
2016
Author
Xu, A;Zhang, L;Chen, Y;Lin, Z;Li, R;
Journal
Cancer Immunol. Immunother.
Title
RegIV 在视网膜母细胞瘤中的表达及其与血管新生的相关性分析
Year
2017
Author
童, 萌;原, 慧;张, 诗;赵, 洋;谭, 欣;
Journal
现代生物医学进展