RSV Fusion (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All RSV Fusion reagents are produced in house and quality controlled, including 3 RSV Fusion Antibody, 2 RSV Fusion ELISA, 40 RSV Fusion Gene, 1 RSV Fusion IP Kit, 2 RSV Fusion Lysate, 2 RSV Fusion Protein. All RSV Fusion reagents are ready to use.

RSV Fusion Protein (2)

RSV Fusion Antibody (3)

RSV Fusion ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

RSV Fusion cDNA Clone (40)

subtype A, strain RSS-2

克隆载体 cDNA 产品

In lentiviral vector

Human Respiratory Syncytial Virus A

克隆载体 cDNA 产品

In expression vector

In lentiviral vector

Subtype A, strain Long
subtype A, strain A2
Subtype A, strain A2001/2-20

In expression vector

In lentiviral vector

RSV Fusion Lysate (2)

RSV Fusion 相关研究领域

RSV Fusion 分子背景

Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneumovirus of the family paramyxoviridae. Like other members of the family, HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. The G protein mediates attachment of the virus to cell surface receptors, while the F protein promotes fusion of the viral and cellular membranes, allowing entry of the virus ribonucleoprotein into the cell cytoplasm. The fusion (F) protein of RSV is synthesized as a nonfusogenic precursor protein (F), which during its migration to the cell surface is activated by cleavage into the disulfide-linked F1 and F2 subunits. This fusion is pH independent and occurs directly at the outer cell membrane, and the F2 subunit was identifed as the major determinant of RSV host cell specificity. The trimer of F1-F2 interacts with glycoprotein G at the virion surface. Upon binding of G to heparan sulfate, the hydrophobic fusion peptide is unmasked and induces the fusion between host cell and virion membranes. Notably, RSV fusion protein is unique in that it is able to interact directly with heparan sulfate and therefore is sufficient for virus infection. Furthermore, the fusion protein is also able to trigger p53-dependent apoptosis.

RSV Fusion 参考文献

  • Martin-Gallardo A. et al., 1993, J Gen Virol. 74 (3): 453-8.
  • Jose A M. et al., 1997, J Gen Virol. 78: 2411-8.
  • Feldman SA. et al., 1999, J Virol. 73 (8): 6610-7.
  • Zlateva K.T. et al., 2004, J Virol. 78 (9): 4675-83.
  • Trento A. et al., 2006, J Virol. 80 (2): 975-84.
  • Branigan P J. et al., 2006, J Gen Virol. 87 (2): 395-8.
  • Eckardt-Michel J. et al., 2008, J. Virol. 82: 3236-49.