CoV spike (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CoV spike reagents are produced in house and quality controlled, including 23 CoV spike Antibody, 60 CoV spike Gene, 17 CoV spike IP Kit, 20 CoV spike Lysate, 28 CoV spike Protein. All CoV spike reagents are ready to use.

CoV spike Antibody (23)

    CoV spike cDNA Clone (60)

    SARS-CoV, isolate CUHK-W1

    In expression vector

    In lentiviral vector

    2019-nCoV

    In expression vector

    In lentiviral vector

    HCoV-HKU1

    In expression vector

    In lentiviral vector

    MERS-CoV

    In lentiviral vector

    CoV spike IP Kit (17)

    CoV spike Lysate (20)

      CoV spike 相关研究领域

      CoV spike 分子背景

      The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.

      CoV spike 参考文献

      • Shen S, et al. (2007) Expression, glycosylation, and modification of the spike (S) glycoprotein of SARS CoV. Methods Mol Biol. 379: 127-35.
      • Du L, et al. (2009) The spike protein of SARS-CoV--a target for vaccine and therapeutic development. Nat Rev Microbiol. 7 (3): 226-36.
      • Xiao X, et al. (2004) The SARS-CoV S glycoprotein. Cell Mol Life Sci. 61 (19-20): 2428-30.

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