14-3-3 beta: 14-3-3 beta protein | 14-3-3 beta antibody

14-3-3 beta General information

14-3-3 beta Reagents


14-3-3 beta Reagents • Recombinant 14-3-3 beta protein • Anti-14-3-3 beta antibody
APPROVED SYMBOL
 YWHAB
APPROVED NAME
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
HGNC ID
 HGNC:12849
SYNONYMS
 14-3-3 alpha, 14-3-3 beta
LOCUS TYPE
 gene with protein product
CHROMOSOMAL LOCATION
 20q13.12
HCOP
Orthology Predictions for YWHAB From HGNC

From HGNC

14-3-3 beta Gene family protein & antibody (14-3-3 phospho-serine/phospho-threonine binding proteins)

Approved Symbol
Common name
Reagent list
SFN
SFN
YWHAG
YWHAG
YWHAQ
YWHAQ
Approved Symbol
Common name
Reagent list
YWHAE
YWHAE
YWHAH
YWHAH
YWHAZ
YWHAZ

14-3-3 beta Gene family members (14-3-3 phospho-serine/phospho-threonine binding proteins)

Approved Symbol
Approved Name
Synonyms
SFN
14-3-3 sigma, YWHAS
YWHAE
14-3-3 epsilon, FLJ45465
YWHAG
14-3-3 gamma, PPP1R170, protein phosphatase 1, regulatory subunit 170
YWHAH
14-3-3 eta
YWHAQ
14-3-3 theta, HS1, HS1, protein tau
YWHAZ
14-3-3 delta, 14-3-3 zeta, 14-3-3-zeta, KCIP-1

14-3-3 beta background

14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 1% identical to the mouse ortholog. 14-3-3 beta / YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. 14-3-3 beta / YWHAB has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation.

Reference for 14-3-3 beta

• Tommerup N, et al. (1996) Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. Genomics. 33(1): 149-50.

• Jin YH, et al. (2008) Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun. 368(3): 690-5.

• Sekimoto T, et al. (2004) 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 23(9): 1934-42.

14-3-3 beta Protein

14-3-3 beta protein function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}.

14-3-3 beta protein sequence

Length: 246.00

Mass (Da): 28.00

This sequence information is just for reference only.From Uniport

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14-3-3 beta Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]

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