Anti-4-1BBL Antibody

4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

• Cancer Immunotherapy
• Co-stimulatory Immune Checkpoint Targets
• Immune Checkpoint
• Immune Checkpoint Detection: Antibodies
• Immune Checkpoint Detection: ELISA Antibodies
• Immune Checkpoint Detection: FCM Antibodies
• Immune Checkpoint Detection: ICC Antibodies
• Immune Checkpoint Targets
• Immunotherapy
• Targeted Therapy

tumor necrosis factor (ligand) superfamily, member 9

• Immune Checkpoint>>Co-stimulatory Immune Checkpoint
• Immunology>>Innate Immunity>>Monocytes/Macrophages>>Co-stimulatory Molecules
• Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>Costimulatory TNF Superfamily Molecules
• Cancer>>Signal Transduction>>Signaling Pathway>>Representative pathway>>Apoptosis Signaling pathway>>Regulation of Apoptosis by TNF Superfamily Members
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily>>Processes Regulated by TNF Superfamily Members>>Regulation of B Cell Activation and Homeostasis by TNF Superfamily Members
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily>>Processes Regulated by TNF Superfamily Members>>Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily>>Processes Regulated by TNF Superfamily Members>>Regulation of T Cell Co-stimulation by TNF Superfamily Members
• Cardiovascular>>Angiogenesis>>Cytokine & Receptor>>Tumor Necrosis Factor (TNF) & Receptor>>TNF Receptor
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily>>TNF Superfamily Ligands

• Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
• Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
• Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.