ADAM17 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All ADAM17 reagents are produced in house and quality controlled, including 4 ADAM17 Antibody, 20 ADAM17 Gene, 1 ADAM17 IP Kit, 1 ADAM17 Lysate, 1 ADAM17 Protein, 3 ADAM17 qPCR. All ADAM17 reagents are ready to use.

ADAM17 分子背景

ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM17 also plays a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes. ADAM17 may play a prominent role in the Notch signaling pathway, during the proteolytic release of the Notch intracellular domain (from the Notch1 receptor) that occurs following ligand binding.

ADAM17 参考文献

  • Poghosyan. et al., 2002, J Biol Chem. 277 (7): 4999-5007.
  • Li Y. et al., 2006, Blood. 108 (7): 2275-9.
  • Peiretti. et al., 2003, J Cell Sci. 116 (10): 1949-57.