ADAMTS4 cDNA ORF Clone in Cloning Vector, Human

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ADAMTS4 cDNA ORF Clone in Cloning Vector, Human: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
2514 bp
序列特征
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 1877 A/G resulting in the amino acid Gln substitution by Arg and 2158 C/G resulting in the amino acid Pro substitution by Ala.
产品特征
Full length Clone DNA of Human ADAM metallopeptidase with thrombospondin type 1 motif, 4.
质粒
测序引物
M13-47 and RV-M
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

ADAMTS4 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ADAMTS4 cDNA ORF Clone in Cloning Vector, Human: 别称

ADAMTS-2 cDNA ORF Clone, Human; ADAMTS-4 cDNA ORF Clone, Human; ADMP-1 cDNA ORF Clone, Human

ADAMTS4 背景信息

ADAMTSs (A disintegrin and metalloprotease domains with thrombospondins motifs) are a family of extracellular proteases that have been related to both oncogenic and tumor-suppressive functions. The ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4) enzyme is a matrix-associated zinc metalloendopeptidase that plays an essential role in the degradation of cartilage aggrecan in arthritic diseases and has been recognized as one of the most primary targets for therapeutic intervention in osteoarthritis (OA). ADAMTS4 knockdown had no inhibitory implications on cell proliferation and invasion in vitro, but significantly attenuated tumor growth in vivo. Mechanistically, we revealed that ADAMTS4 was associated macrophages infiltration and polarization in the tumor microenvironment of CRC. Macrophage depletion largely abolished the promotive effect of ADAMTS4 on tumor growth in the immune competent BALB/c mice. CONCLUSION: ADAMTS4 seemed to be a promising prognostic indicator in CRC. The novel link between ADAMTS4 and macrophages mirrors the potential regulatory roles of ADAMTSs in the inflammatory microenvironment of cancers. Host-derived ADAMTS4 was expressed at the tumor vessels and was associated with early-stage tumor growth. ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4) is a pathogenic factor of plaque vulnerability in mice. ADAMTS4 may be a potential biomarker for plaque vulnerability.
全称
ADAM metallopeptidase with thrombospondin type 1 motif, 4
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