Anti-CTHRC1 Antibody

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Anti-CTHRC1 Antibody (Rabbit Polyclonal 抗体) 产品信息

产品名称
Anti-CTHRC1 Antibody
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Rat
特异性
Rat CTHRC1
免疫原
Recombinant Rat CTHRC1 Protein (Catalog#80712-R08H)
制备方法
Produced in rabbits immunized with purified, recombinant Rat CTHRC1 (rR CTHRC1; Catalog#80712-R08H; NP_001258229.1; Met1-Lys230). CTHRC1 specific IgG was purified by Rat CTHRC1 affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CTHRC1 Antibody (Rabbit Polyclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CTHRC1 Antibody (Rabbit Polyclonal 抗体) 图片

Immunochemical staining of rat CTHRC1 in rat kidney with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.
Immunochemical staining of rat CTHRC1 in rat stomach with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.

CTHRC1 背景信息

Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.
全称
collagen triple helix repeat containing 1
参考文献
  • Pyagay P, et al. (2005) Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ Res. 96(2): 261-8.
  • Durmus T, et al. (2006) Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1). Gene Expr Patterns. 6(8): 935-40.
  • LeClair R, et al. (2007) The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling. Trends Cardiovasc Med. 17(6): 202-5.
  • Kimura H, et al. (2008) Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS One. 3(9): e3174.
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