BMP-2 Protein, Human, Recombinant

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BMP-2 Protein, Human, Recombinant: 产品信息

纯度
> 95 % as determined by SDS-PAGE
内毒素
Please contact us for more information.
生物活性
Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.1-0.5μg/mL.
蛋白构建
A DNA sequence encoding the mature form of human BMP2 (NP_001191.1) (Gln283-Arg396) was expressed. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical.
NP No.
表达宿主
E. coli
种属
Human
预测 N 端
Met
分子量
The recombinant human BMP2 monomer consists of 115 amino acids and has a predicted molecular mass of 13 kDa.
缓冲液
Lyophilized from sterile 30 % CAN, 0.1 % TFA, pH 2.9.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BMP-2 Protein, Human, Recombinant: 图片

BMP-2 Protein, Human, Recombinant: 别称

BDA2 Protein, Human; BDA2A Protein, Human; BMP-2 Protein, Human; BMP2A Protein, Human

BMP-2 背景信息

BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.
全称
bone morphogenetic protein 2
参考文献
  • Jiao X, et al. (2007) Heparan sulfate proteoglycans (HSPGs) modulate BMP-2 osteogenic bioactivity in C2C12 cells. J Biol Chem. 282(2):1080-6.
  • Michon F, et al. (2008) BMP-2 and BMP-7 play antagonistic roles in feather induction. Development 135 (16):2797-805.
  • Preparation and Evaluation of a CD13/APN-Targeting and Hydrolase-Resistant Conjugate that Comprises Pingyangmycin and NGR Motif-Integrated Apoprotein
    Author
    Li, B;Zheng, YB;Li, DD;Zhen, YS;
    Year
    2014
    Journal
    J Pharm Sci
  • Characterization of BMP signaling dependent osteogenesis using a BMP depletable avianized bone marrow stromal cell line (TVA-BMSC)
    Author
    Yadav, PS;Khan, MP;Prashar, P;Duggal, S;Rath, SK;Chattopadhyay, N;Bandyopadhyay, A;
    Year
    2016
    Journal
    Bone
    Application
    cell based
  • Heterologous Secretory Expression and Characterization of Dimerized Bone Morphogenetic Protein 2 in Bacillus subtilis
    Author
    Hanif, MU;Gul, R;Hanif, MI;Hashmi, AA;
    Year
    2017
    Journal
    BioMed Research International
    Application
    cell-based (induction)
  • Small Ubiquitin-Like Modifier Protein 3 Enhances the Solubilization of Human Bone Morphogenetic Protein 2 in E. coli
    Author
    Hanif, MU;Yaseen, A;Gul, R;Mirza, MU;Nawaz, MH;Ahmed, SS;Aziz, S;Chaudhary, S;Khan, AA;Shoaib, M;
    Year
    2018
    Journal
    Appl. Biochem. Biotechnol.
    Application
    cell-based
  • OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ
    Author
    Zhang, Z;Du, J;Wang, S;Shao, L;Jin, K;Li, F;Wei, B;Ding, W;Fu, P;van Dam, H;Wang, A;Jin, J;Ding, C;Yang, B;Zheng, M;Feng, XH;Guan, KL;Zhang, L;
    Year
    2018
    Journal
    Mol. Cell
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