Anti-Nectin-2 Antibody (PE)

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Anti-Nectin-2 Antibody (PE) (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-Nectin-2 Antibody (PE)
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human Nectin-2
免疫原
Recombinant Human CD112 / Nectin-2 protein (Catalog#10005-H08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD112 / Nectin-2 (rh CD112 / Nectin-2; Catalog#10005-H08H; NP_002847.1; Met1-Leu360) and conjugated with PE under optimum conditions, the unreacted PE was removed.
来源
Monoclonal Rabbit IgG Clone #005
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
偶联物
PE
浓度
10 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Anti-Nectin-2 Antibody (PE) (Rabbit Monoclonal 抗体) 图片

Flow cytometric analysis of anti-Human PVRL2(CD112) on A549 cells.

Anti-Nectin-2 Antibody (PE): 别称

Anti-CD112 Antibody; Anti-HVEB Antibody; Anti-Nectin-2 Antibody; Anti-PRR2 Antibody; Anti-PVRR2 Antibody

Nectin-2 背景信息

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
全称
poliovirus receptor-related 2 (herpesvirus entry mediator B)
参考文献
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
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