Anti-Thy1 / CD90 Antibody

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Anti-Thy1 / CD90 Antibody (Rabbit Polyclonal 抗体) 产品信息

产品名称
Anti-Thy1 / CD90 Antibody
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Mouse
特异性
Mouse Thy1 / CD90
免疫原
Recombinant Mouse THY1 protein (Catalog#50461-M08H)
制备方法
Produced in rabbits immunized with purified, recombinant Mouse THY1 (rM THY1; Catalog#50461-M08H; NP_033408.1; Met 1-Cys 131). THY1 specific IgG was purified by mouse THY1 affinity chromatography .
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Thy1 / CD90 Antibody (Rabbit Polyclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:1000-1:4000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Thy1 / CD90 Antibody (Rabbit Polyclonal 抗体) 图片

Immunochemical staining of mouse THY1 in rat retina with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections). Positive staining was localized to ganglion cells.
Immunochemical staining of mouse THY1 in rat kidney with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections). Positive staining was localized to renal glomerulus.
Immunochemical staining of mouse THY1 in rat brain with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).

Anti-Thy1 / CD90 Antibody: 别称

Anti-CD90 Antibody; Anti-T25 Antibody; Anti-Thy-1 Antibody; Anti-Thy-1.2 Antibody; Anti-Thy1.1 Antibody; Anti-Thy1.2 Antibody

Thy1 / CD90 背景信息

Thy-1 membrane glycoprotein, also known as Thy-1 antigen, CD9 and THY1, is a cell membrane protein which contains 1 Ig-like V-type (immunoglobulin-like) domain. It is a glycophosphatidylinositol-linked glycoprotein expressed on the surface of neurons, thymocytes, subsets of fibroblasts, endothelial cells, mesangial cells and some hematopoietic cells. It has been identified on a variety of stem cells and at varying levels in non-lymphoid tissues such as on fibroblasts, brain cells, and activated endothelial cells. Thy-1 is evolutionarily conserved, developmentally regulated, and often has dramatic effects on cell phenotype. Thy-1 is a 25-37 kDa glycosylphosphatidylinositol (GPI)-anchored protein involved in T cell activation, neurite outgrowth, apoptosis, tumor suppression, wound healing, and fibrosis. To mediate these diverse effects, Thy-1 participates in multiple signaling cascades. Thy-1 is an important regulator of cell-cell and cell-matrix interactions, with important roles in nerve regeneration, metastasis, inflammation, and fibrosis.
全称
Thy-1 cell surface antigen
参考文献
  • Rege TA, et al. (2006) Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis. FASEB J. 20(8): 1045-54.
  • Fiegel HC, et al. (2008) Lack of Thy1 (CD90) expression in neuroblastomas is correlated with impaired survival. Pediatr Surg Int. 24(1): 101-5.
  • Bradley JE, et al. (2009) Roles and regulation of Thy-1, a context-dependent modulator of cell phenotype. Biofactors. 35(3): 258-65.
  • Kisselbach L, et al. (2009) CD90 Expression on human primary cells and elimination of contaminating fibroblasts from cell cultures. Cytotechnology. 59(1): 31-44.
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