Carbonic Anhydrase VB (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Carbonic Anhydrase VB reagents are produced in house and quality controlled, including 5 Carbonic Anhydrase VB Antibody, 15 Carbonic Anhydrase VB Gene, 1 Carbonic Anhydrase VB IP Kit, 1 Carbonic Anhydrase VB Protein, 1 Carbonic Anhydrase VB qPCR. All Carbonic Anhydrase VB reagents are ready to use.

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Carbonic Anhydrase VB 相关研究领域

Carbonic Anhydrase VB 分子背景

Carbonic anhydrase 5B, also known as carbonate dehydratase VB, carbonic anhydrase VB, CA-VB and CA5B, is amember of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart, pancreas, kidney, placenta, lung, and skeletal muscle. It is not expressed in liver. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CAs show extensive diversity in tissue distribution and in their subcellular localization. CA5B / CA-VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA5A / CA-VA. CA5B / CA-VB has a wider tissue distribution than CA5A / CA-VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. CA5A / CA-VA is activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. It is inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt). CA5B / CA-VB is inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).

Carbonic Anhydrase VB 参考文献

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