GRK6 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All GRK6 reagents are produced in house and quality controlled, including 1 GRK6 Lysate, 1 GRK6 Protein. All GRK6 reagents are ready to use.

GRK6 相关研究领域

GRK6 分子背景

G protein-coupled receptor kinase 6, also known as G protein-coupled receptor kinase GRK6, GRK6 and GPRK6, is a lipid-anchor protein which belongs to theprotein kinase superfamily, AGC Ser/Thr protein kinase family and GPRK subfamily. GRK6 / GPRK6 contains oneAGC-kinase C-terminal domain, oneprotein kinase domain and oneRGS domain. This protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described. GRK6 / GPRK6 is widely expressed. GRK6 / GPRK6 silencing causes suppression of signal transducer and activator of transcription 3 (STAT3) phosphorylation associated with reduction in MCL1 levels and phosphorylation, illustrating a potent mechanism for the cytotoxicity of GRK6 inhibition in multiple myeloma (MM) tumor cells. GRK6 also appears to be involved in responses to morphine. Inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.

GRK6 参考文献

  • Ghadessy,R.S. et al., 2003, Br J Pharmacol  138 (4):660-70.
  • Murga,C. et al., 2009, Brain Behav Immun. 23 (1):16-7.
  • Tiedemann,R.E. et al., 2010, Blood  115 (8):1594-604.
  • Ahmed,M.R. et al., 2010, Sci Transl Med 2 (28): 28ra28.