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HDAC1 相关研究领域

HDAC1 相关信号通路

HDAC1 相关蛋白、抗体、cDNA基因、ELISA试剂盒

HDAC1 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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HDAC1 概述&蛋白信息

HDAC1 研究背景

催化活性: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
亚单位结构: Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Found in a trimeric complex with APBB1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3. Component of a RCOR/GFI/KDM1A/HDAC complex. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with the non-histone region of H2AFY. Interacts with TRIM28; the interaction recruits HDAC1 to E2F1 and inhibits its acetylation. Interacts with SP1; the interaction deacetylates SP1 and regulates its transcriptional activity. Interacts with SP3; the interaction deacetylates SP3 and regulates its transcriptional activity. In vitro, C(18) ceramides increase this interaction and the subsequent SP3 deacetylation and SP3-mediated repression of the TERT promoter. Interacts with TSHZ3 (via N-terminus); the interaction is direct. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with C10orf90/FATS (via its N-terminal); the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. Interacts with CDKN1A/p21. Interacts with CDK5 complexed to CDK5R1 (p25). Interacts directly with GFI1 and GFI1B. Interacts with NR1D2 (via C-terminus). Interacts with TSC22D3 isoform 1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity. Interacts with BAZ2A/TIP5, BANP, BCL6, BCOR, BHLHE40/DEC1, BRMS1, BRMS1L, CBFA2T3, CHFR, CIART, CRY1, DAXX, DDIT3/CHOP, DDX5, DNMT1, E4F1, EP300, HCFC1, HDAC9, INSM1, NFE4, NR4A2/NURR1, MIER1, KDM4A, KDM5B, KLF1, MINT, NRIP1, PCAF, PHB2, PRDM6, PRDM16, RB1, RERE, SAMSN1, SAP30L, SETDB1, SMAD3, SMARCA4/BRG1, SMYD2, SUV39H1, TGIF, TGIF2, TRAF6, UHRF1, UHRF2, ZMYND15, ZNF431 and ZNF541. Interacts with KDM5A (By similarity). {ECO:0000250|UniProtKB:O09106, ECO:0000269|PubMed:10487760, ECO:0000269|PubMed:10655483, ECO:0000269|PubMed:10669754, ECO:0000269|PubMed:10846170, ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:11006275, ECO:0000269|PubMed:11102443, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:11427533, ECO:0000269|PubMed:11533236, ECO:0000269|PubMed:12482978, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:12730668, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:14633989, ECO:0000269|PubMed:15273251, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:15451426, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16166625, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:16820529, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17341466, ECO:0000269|PubMed:17369852, ECO:0000269|PubMed:17373667, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17872950, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:18093978, ECO:0000269|PubMed:19049980, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19182791, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:21829689}.
亚细胞定位: Nucleus.
组织特异性: Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
翻译后修饰: Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1. {ECO:0000269|PubMed:11960997, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15199155}.; Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5. {ECO:0000269|PubMed:11602581}.; Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by KCTD11, leading to proteasomal degradation. {ECO:0000269|PubMed:19182791, ECO:0000269|PubMed:20081843}.
相似的序列: Belongs to the histone deacetylase family. HD type 1 subfamily. {ECO:0000305}.
General information above from UniProt

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. Histone Deacetylase 1 protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

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HDAC1 别称

HD1,RPD3,GON-10,RPD3L1, [homo-sapiens]
HD1,RPD3,MommeD5,Hdac1-ps, [mus-musculus]

HDAC1 相关文献

  • Beharry AW, Sandesara PB, Roberts BM, Ferreira LF, Senf SM, Judge AR. HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy. Journal of Cell Science. 2014;127(7):1441-1453.
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