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HDAC3 相关研究领域

HDAC3 相关信号通路

HDAC3 相关蛋白、抗体、cDNA基因、ELISA试剂盒

HDAC3 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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HDAC3 概述&蛋白信息

HDAC3 研究背景

基因概述: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC3 gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
General information above from NCBI
催化活性: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
亚单位结构: Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15. Interact with SMRT/NCOR2 and BCL6 on DNA enhancer elements. Interacts with INSM1 (PubMed:10655483, PubMed:10669754, PubMed:10860984, PubMed:10898795, PubMed:11006275, PubMed:11466315, PubMed:11533236, PubMed:11861901, PubMed:14525983, PubMed:14633989, PubMed:15297880, PubMed:15927959, PubMed:16569215, PubMed:18417529, PubMed:19409814, PubMed:23911289). Interacts with XBP1 isoform 1; the interaction occurs in endothelial cell (EC) under disturbed flow (PubMed:25190803). {ECO:0000269|PubMed:10655483, ECO:0000269|PubMed:10669754, ECO:0000269|PubMed:10860984, ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:11006275, ECO:0000269|PubMed:11466315, ECO:0000269|PubMed:11533236, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:14525983, ECO:0000269|PubMed:14633989, ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:25190803}.
亚细胞定位: Nucleus. Cytoplasm {ECO:0000269|PubMed:25190803}. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). {ECO:0000269|PubMed:25190803}.
组织特异性: Widely expressed.
诱导: Up-regulated by disturbed flow in umbilical vein endothelial cells in vitro (PubMed:25190803).
翻译后修饰: Sumoylated in vitro. {ECO:0000269|PubMed:12032081}.
相似的序列: Belongs to the histone deacetylase family. HD type 1 subfamily. {ECO:0000305}.
General information above from UniProt

Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents. Histone Deacetylases (HDACs) is Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

HDAC3 别称

RPD3,HD3,RPD3-2, [homo-sapiens]
HD3,HDAC3,RPD3,RPD3-2, [human]
AW537363,Hdac3, [mouse]
AW537363, [mus-musculus]

HDAC3 相关文献

  • Emiliani S, et al. (1998) Characterization of a human RPD3 ortholog, HDAC3. Proc Natl Acad Sci. 95 (6): 2795-800.
  • Dangond F, et al. (1998) Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells. Biochem Biophys Res Commun. 242 (3): 648-52.
  • Nicolas E, et al. (2001) The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein. Nucleic Acids Res. 29 (15): 3131-6.
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