Her2 / ERBB2 Protein, Rhesus, Recombinant (His Tag)


Her2 / ERBB2 Protein, Rhesus, Recombinant (His Tag): 产品信息

> 95 % as determined by SDS-PAGE
< 1.0 EU per μg of the protein as determined by the LAL method
Measured by its binding ability in a functional ELISA . Immobilized rhesus Erbb2 at 2.5 μg/ml (100 μl/well) can bind Herceptin with a linear ranger of 6.4-160 ng/ml.
A DNA sequence encoding the Rhesus ErbB2 (XP_001090430.1) extracellular domain (Met 1-Thr 652) was fused with a polyhistidine tag at the C-terminus.
NCBI Reference No.
HEK293 Cells
预测 N 端
Gln 24
The recombinant Rhesus ErbB2 consists of 640 amino acids and predicts a molecular mass of 70.7 kDa. As a result of glycosylation, rhesus ErbB2 migrates as an approximately 105 kDa band in SDS-PAGE under reducing conditions.
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Her2 / ERBB2 Protein, Rhesus, Recombinant (His Tag): 图片

Her2 / ERBB2 背景信息

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD34, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
erb-b2 receptor tyrosine kinase 2
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
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