IL-15 Protein, Human, Recombinant

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IL-15 Protein, Human, Recombinant: 产品信息

纯度
> 95 % as determined by SDS-PAGE.
内毒素
< 0.01 EU per μg of the protein as determined by the LAL method
生物活性
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells.
The ED50 for this effect is typically 2-8 ng/mL.
The specific activity of Recombinant Human IL-1β is approximately 2.4×10E5 units/μg.
蛋白构建
A DNA sequence encoding the human IL15 (NP_000576.1) (Asn49-Ser162) was expressed.
NP No.
表达宿主
E. coli
种属
Human
预测 N 端
Asn 49
分子量
The recombinant human IL15 consists of 114 amino acids and predicts a molecular mass of 12.8 kDa.
缓冲液
Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL-15 Protein, Human, Recombinant: 图片

Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 for this effect is typically 2-8 ng/mL.

IL-15 Protein, Human, Recombinant: 别称

IL-15 Protein, Human; Interleukin 15 Protein, Human

IL-15 背景信息

The protein encoded by IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
全称
interleukin 15
参考文献
  • Mongini PKA, Gupta R, Boyle E, et al. TLR-9 and IL-15 synergy promotes the in vitro clonal expansion of chronic lymphocytic leukemia B cells. Journal of immunology (Baltimore, Md : 1950). 2015;195(3):901-923.
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