Anti-IFNAR1 Antibody

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Anti-IFNAR1 Antibody (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-IFNAR1 Antibody
经验证的应用
ELISA(Cap)
交叉反应
Reacts with: Mouse
特异性
Mouse IFNAR1
免疫原
Recombinant Mouse IFNAR1 Protein (Catalog#50469-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IFNAR1 (rM IFNAR1; Catalog#50469-M08H; NP_034638.2; Met1-Thr429).
来源
Monoclonal Rabbit IgG Clone #120
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-IFNAR1 Antibody (Rabbit Monoclonal 抗体) 经验证的应用

Notes
ELISA(Cap): This antibody will detect Mouse IFNAR1 in ELISA pair set (Catalog: # SEK50469). In a sandwich ELISA, it can be used as capture antibody.
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-IFNAR1 Antibody: 别称

Anti-CD118 Antibody; Anti-Ifar Antibody; Anti-Ifnar Antibody; Anti-Ifrc Antibody; Anti-Infar Antibody

IFNAR1 背景信息

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
全称
interferon (alpha, beta and omega) receptor 1
参考文献
  • Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
  • Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
  • Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.
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