IFNAR1 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All IFNAR1 reagents are produced in house and quality controlled, including 13 IFNAR1 Antibody, 2 IFNAR1 ELISA, 41 IFNAR1 Gene, 1 IFNAR1 IP Kit, 6 IFNAR1 Lysate, 6 IFNAR1 Protein, 3 IFNAR1 qPCR. All IFNAR1 reagents are ready to use.

IFNAR1 Protein (6)

IFNAR1 Antibody (13)

IFNAR1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

IFNAR1 cDNA Clone (41)

NM_000629.2

克隆载体 cDNA 产品

In lentiviral vector

NM_010508.2

克隆载体 cDNA 产品

In lentiviral vector

NM_001105893.1

克隆载体 cDNA 产品

In lentiviral vector

XM_001092098.2

克隆载体 cDNA 产品

In lentiviral vector

IFNAR1 Lysate (6)

IFNAR1 分子背景

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

IFNAR1 参考文献

  • Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
  • Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
  • Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.