IL3 Protein, Human, Recombinant

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IL3 Protein, Human, Recombinant: 产品信息

纯度
> 95 % as determined by SDS-PAGE.
内毒素
Please contact us for more information.
生物活性
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.1-0.6ng/ml.
蛋白构建
A DNA sequence encoding the human IL3 (NP_000579.2) (Ala20-Phe152) was expressed with an initial Met.
NP No.
表达宿主
E. coli
种属
Human
预测 N 端
Met
分子量
The recombinant human IL3 consists 134 amino acids and predicts a molecular mass of 15.2 kDa.
缓冲液
Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL3 Protein, Human, Recombinant: 图片

IL3 Protein, Human, Recombinant: 别称

IL-3 Protein, Human; Interleukin-3 Protein, Human; MCGF Protein, Human; MULTI-CSF Protein, Human

IL3 背景信息

IL3 (interleukin 3), also known as IL-3, is a potent growth promoting cytokine which belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells. IL3/IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
全称
interleukin 3
参考文献
  • Meyer CG, et al.. (2011) IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks. Hum Mol Genet. 20(6):1173-81.
  • Zambrano A, et al. (2010) IL-3 controls tau modifications and protects cortical neurons from neurodegeneration. Curr Alzheimer Res. 7(7):615-24.
  • Dentelli P, et al.. (2011) IL-3 is a novel target to interfere with tumor vasculature. Oncogene. 30(50):4930-40.
  • Automating hESC differentiation with 3D printing and legacy liquid handling solutions
    Author
    Zluhan, E;Kelly, K;LeClair, N;Wortel, D;Moody, K;
    Year
    2016
    Journal
    MethodsX
    Application
    culture
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