AMPK alpha 1 / PRKAA1 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All AMPK alpha 1 / PRKAA1 reagents are produced in house and quality controlled, including 1 AMPK alpha 1 / PRKAA1 Antibody, 15 AMPK alpha 1 / PRKAA1 Gene, 1 AMPK alpha 1 / PRKAA1 qPCR. All AMPK alpha 1 / PRKAA1 reagents are ready to use.

AMPK alpha 1 / PRKAA1 分子背景

The PRKAA1 gene encodes the catalytic alpha-subunit of 5' AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor that maintains energy homeostasis within the cell and is activated when the AMP/ATP ratio increases. Moreover, AMPK has been shown to be involved in inhibiting tumour growth and metastasis, and has also been implicated in the pathology of neurodegenerative and cardiac disorders. All 5 tested tag SNPs of the PRKAA1 gene (rs1336177, rs154268, rs385486, rs688293, and rs174991) were significantly associated with gastric cancer.An inhibitor of PRKAA1 promoted the secretion of IL6, whereas an agonist of PRKAA1 suppressed the production of IL6.