S6K1 / RPS6KB1 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All S6K1 / RPS6KB1 reagents are produced in house and quality controlled, including 2 S6K1 / RPS6KB1 Antibody, 32 S6K1 / RPS6KB1 Gene, 1 S6K1 / RPS6KB1 IP Kit, 1 S6K1 / RPS6KB1 Lysate, 1 S6K1 / RPS6KB1 Protein, 1 S6K1 / RPS6KB1 qPCR. All S6K1 / RPS6KB1 reagents are ready to use.

S6K1 / RPS6KB1 分子背景

PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p7 ribosomal S6 kinase (S6K). S6K can be activated by mitogenic stimuli such as growth factors, insulin and cytokines. It phosphorylates the ribosomal protein S6. PS6K also phosphorylates other proteins such as elF4B, eEF2K and SKAR. It is a crucial effector of mTOR(rapamycin) signaling. PS6K is dissociated from the EIF3 complex and activated upon mitogenic stimulation, phosphorylation by the mammalian target of mTOR complex 1 (mTORC1). Its active form then phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. PS6K also functions in cell proliferation, cell growth and cell cycle progression.

S6K1 / RPS6KB1 参考文献

  • Panasyuk, et al. (2006) Nuclear export of PS6K II is regulated by protein kinase CK2 phosphorylation at Ser-17. J Biol Chem. 281(42):31188-201.
  • Carnevalli L, et al. (2010) PS6K Plays a Critical Role in Early Adipocyte Differentiation. Dev Cell. 18 (5):763-74.
  • Grove JR, et al. (1991) Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Mol Cell Biol. 11(11):5541-50.